Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cutaneous Squamous Cell Carcinoma
- Sponsor
- Ruhr University of Bochum
- Enrollment
- 7
- Locations
- 1
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.
Detailed Description
Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).
Investigators
Michael Sand
Principal Investigator
Ruhr University of Bochum
Eligibility Criteria
Inclusion Criteria
- •cutaneous squamous cell carcinoma
Exclusion Criteria
- •other skin cancer than cutaneous squamous cell carcinoma
Outcomes
Primary Outcomes
Not specified