Interferon beta 1b in COVID-19
Phase 2
Recruiting
- Conditions
- COVID-19 pneumonia.COVID-19, virus identifiedU07.1
- Registration Number
- IRCT20190804044429N1
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
All adult patients with highly suspected or confirmed COVID-19 who are candidate for hospitalization and starting therapeutic regimen with lopinavir/ritonavir and hydroxychloroquine
Exclusion Criteria
History of allergy to any drugs of therapeutic regimen , pregnancy and lactation, renal and hepatic disease, heart failure, uncontrolled depression and untreated thyroid disorders and seizure history.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical response to therapeutic regimen by respiratory rate. Timepoint: Daily. Method of measurement: physical exam.;Clinical response to therapeutic regimen by blood oxygen saturation. Timepoint: daily. Method of measurement: pulse oximeter.;Clinical response to therapeutic regimen by fever. Timepoint: daily. Method of measurement: thermometer.;Therapeutic regimen safety. Timepoint: daily. Method of measurement: patient tolerability.;LDH level reduction. Timepoint: three times weekly. Method of measurement: laboratory test.;CRP level reduction. Timepoint: three times weekly. Method of measurement: laboratory test.;Lymphocyte count recovery. Timepoint: daily. Method of measurement: laboratory test.;Cough recovery. Timepoint: daily. Method of measurement: physical exam.
- Secondary Outcome Measures
Name Time Method Injection site reactions,. Timepoint: Daily. Method of measurement: history taking.;Hospital stay duration. Timepoint: End of treatment. Method of measurement: Patient file.;Mortality rate. Timepoint: Daily. Method of measurement: patient file.;Flu-like symptoms. Timepoint: Daily. Method of measurement: history taking.;Liver enzymes changing. Timepoint: twice weekly. Method of measurement: laboratory test.