Exercise Prebreathe Study in Healthy Adult Volunteers to Evaluate Risk of Decompression Sickness During Simulated Spacewalk Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Duke University
- Enrollment
- 30
- Primary Endpoint
- Number of participants with Decompression Sickness
Study Overview
Brief Summary
This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 30 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Non-smoking volunteers aged 30-60 years
- •Able to meet VO2 peak requirements (>35 ml/kg/min males, >30 ml/kg/min females)
Exclusion Criteria
- •Pregnancy
- •Lung disease, heart disease, hypertension, or diabetes
- •Musculoskeletal pain conditions
- •Requirement for regular medications such as analgesics
Arms & Interventions
Single Arm
Participants undergo oxygen prebreathe followed by hypobaric chamber exposure with exercise and monitoring.
Intervention: Oxygen Prebreathe and Hypobaric Exposure (Procedure)
Outcomes
Primary Outcomes
Number of participants with Decompression Sickness
Time Frame: Up to 6 months
Decompression sickness will be recorded during Extravehicular Activity (EVA) simulation at 6.2 psia following a one-hour oxygen prebreathe while resting, performing light exercise or heavier exercise.
Secondary Outcomes
No secondary outcomes reported