Serum calcium, magnesium and calcium magnesium ratio in women with preeclampsia A prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 158
- 试验地点
- 1
- 主要终点
- 1.The serum calcium magnesium ratio in preeclampsia and to compare it with normotensive pregnant woman using maternal serum anylates.
研究概览
简要总结
Written and informed consent from the patient will be taken during the booking visit. Maternal characteristics like weight, height, BMI will be noted.Demographic details like age, parity, medical, surgical, menstrual, family history of the patient will entered. General physical examination and baseline laboratory investigations be done. About 5 ml of venous blood from the antecubital vein without stasis will be collected and sent for serum calcium and magnesium analysis on OPD basis. Urinalysis will be performed using a semi qualitative method. All pregnant women included in the study will be advised to come to the antenatal care clinic monthly till 28 weeks, every 2 weeks till 36 weeks and weekly till delivery during which first, second and third trimester details will be noted. Warning signs will be clearly explained. Patients will be followed up until delivery and also till discharge from the hospital to note down the delivery and neonatal outcomes. Gestational age at delivery ,Mode of delivery, Neonatal outcomes like birth weight,APGAR score at 1 minute and 5 minutes, NICU admissions and complications will be noted. A lower serum Calcium and magnesium ratio among women with pre-eclampsia is expected.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •For cases Pregnant women with a gestational age of 20 weeks or more diagnosed with preeclampsia using the standard criteria including elevated blood pressure greater than or equal to SBP 140 and DBP 90 mm Hg with proteinuria greater than 1 For controls: Normotensive participants without dipstick proteinuria matched for age, gestational, age, and parity.
排除标准
- •1.Women with chronic hypertension 2.Multiple gestation pregnancy 3.Diabetic women 4.Woman with eclampsia 5.Woman with thyroid disease 6.Woman with autoimmune disease 7.Woman with renal disease 8.Woman with History of smoking or alcohol consumption 9.Woman on other drugs effecting blood pressure.
结局指标
主要结局
1.The serum calcium magnesium ratio in preeclampsia and to compare it with normotensive pregnant woman using maternal serum anylates.
时间窗: Serum calcium and magnesium levels will be assessed at the time of diagnosis of preeclampsia ( after 20 weeks ) and controls will be matched for the gestational age.
2.Prevalence of hypomagnesemia and hypocalcemia among study participants
时间窗: Serum calcium and magnesium levels will be assessed at the time of diagnosis of preeclampsia ( after 20 weeks ) and controls will be matched for the gestational age.
3. The association between calcium- magnesium ratio and severity of pre-eclampsia
时间窗: Serum calcium and magnesium levels will be assessed at the time of diagnosis of preeclampsia ( after 20 weeks ) and controls will be matched for the gestational age.
次要结局
- Neonatal Outcomes(post delivery)
- Prevalence of hypomagnesemia and hypocalcemia among study participants(Serum calcium and magnesium levels will be assessed at the time of diagnosis of preeclampsia ( after 20 weeks ) and controls will be matched for the gestational age.)