ADDICTOlogical Intervention in LIVEr Transplantation Recipients
- Conditions
- Alcohol Associated Liver DiseaseLiver Transplantation
- Interventions
- Other: Post-transplant addiction intervention
- Registration Number
- NCT06472973
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Transplantation for end-stage-liver disease (ESLD) in the context of Alcohol-Associated Liver Disease (AALD) has been increasing and represents the main indication for Liver Transplantation (LT) in the world. Alcohol Use Disorder (AUD) is considered a brain chronic disease and requires a transdisciplinary approach that includes medical treatment and behavioral interventions.
In the context of LT, alcohol relapse occurs in 26 % up to 50% of LT recipients. Among Liver transplant recipients for AALD, severe alcoholic relapse (defined as more than 3 alcoholic drinks per day for women and 4/day for men) after LT leads to impaired longterm survival due to recurrent alcoholic cirrhosis (RAC), cardiovascular events and de novo cancer.
Several strategies have been developed to prevent alcohol relapse. After LT, integrating an addiction team into the LT program has been advocated by the latest guidelines in Europe and the United States, in order to bring the management of alcohol-use disorder (AUD) in transplantation units, through the association of psychosocial and pharmacological interventions previously reported in AALD. However, those guidelines were based on descriptive studies, and the effect of this management needs to be confirmed through a randomized, controlled, multicenter study, involving centers that still do not include an addiction team in their LT programs.
This study will therefore assess prospectively and comparatively the impact of an addiction intervention after LT on return to alcohol use rates. We hypothesize that standardized targeted addiction monitoring of Liver Transplant recipients decreases the rates of alcohol relapse two years post-liver transplantation.
- Detailed Description
Liver transplantation (LT) is the only curative option for end-stage liver disease and unresectable hepatocellular carcinoma (HCC) without extrahepatic spread. Alcohol Associated Liver Disease (AALD) has become the most common indication for liver transplantation (LT) in many Western countries.In France, AALD accounts for at least 40% of all LT, between decompensated cirrhosis and HCC, which represents more than 500 patients each year.
One, five and 10-year graft rate and patient survival rate after LT for AALD are at least comparable to those of other indications. Nevertheless, long-term survival rates are hampered by frequent and/or excessive relapse in alcohol consumption. Relapse increases the risk of recurrent alcohol-associated cirrhosis but also of de novo alcohol-induced solid malignancies, mainly cancers of the upper aero digestive tract. Graft and patient survival rates, especially long-term, are thus hindered by the occurrence of excessive relapse.
Relapse rates vary immensely between studies and there is a lack of standardization in the definition of its severity, mainly because it is impossible to define the boundaries/thresholds for "safe consumption". However, there is consensus that harm appears for alcohol intake exceeding three portions per day for males and two for females, for at least 100 days with a sense of loss of control. This pattern of relapse, often described as "severe" can be found between 10 and 26% of patients. Most efforts aiming to reduce post-LT relapse rates focus on improving patient selection. Risk-factors of alcohol relapse often found in literature include short duration of pre-LT sobriety (\<6 months), diagnosis of alcohol dependence, family history of alcohol-use disorder, psychiatric comorbidities including other substance abuse, prior alcohol rehabilitation and female gender. Scores such as HRAR (High Risk Alcoholism Relapse) have also attempted to stratify relapse risk based on pre-LT risk factors. Unfortunately, these criteria are not sensitive enough and most patients who finally benefit from the intervention are in the low to medium risk groups.
It is therefore a priority to utilize also resources in the post-LT setting to decrease alcohol relapse since it is a frequent and relatively difficult to predict event, with a high impact on outcomes after LT. We hypothesize that post-transplant addiction specialist interventions in liver transplant patients with AALD as primary or secondary indication will result in decreased regular and/or severe alcohol relapse rate two years post-LT. By extension, this could result in higher graft and patient survival rates, especially in long term.
More recently, our group has performed a retrospective analysis of three centers with different addiction follow-up practices suggesting a benefit on severe relapse rates of addiction specialist intervention after LT for AALD. However, the main limit of this work is the retrospective design with different follow-up periods and duration. We designed a multicenter superiority randomized controlled trial with 2 parallel arms:
* Interventional arm where participants are offered targeted addictology follow-up and participate in addiction consultations
* Control arm where participants have classical follow-up by the transplant specialists of the LT center during the post-transplant follow-up period
The randomization will be elaborated using 1:1 ratio and minimization method. It will be stratified on centers and alcohol consumption history.
According to a French cohort study of patients with liver transplantation for alcohol-related disorders, 25% of them relapsed at 2 years.To account for mortality censoring during follow-up, we will apply a 5% increase of the sample size to reach 720 participants (360 in each arm). The comparison of the primary endpoint between arms will be carried out using intention to treat principle. The time to relapse will be expressed using Kaplan-Meier curves in each arm, and compared using a log-rank test. The effect size will be estimated using Cox proportional.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 720
- Aged 18 years or above
- Hospitalized for LT for AALD as primary or secondary indication
- Discharged from intensive care unit to hepatology or surgery wards
-
Having a longitudinal pre-transplant addiction follow-up defined by at least 3 appointments within the last 6 months or a temporary contraindication to LT due to alcohol consumption while on the waiting list
-
Severe alcohol-associated hepatitis as primary indication for liver transplantation
-
Impossibility of patient follow up over the next 2 years
-
General criteria:
- Refusal or absence of informed consent,
- Non-affiliation to the French national health insurance,
- Persons placed under legal protection, guardianship or curatorship
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Interventional group Post-transplant addiction intervention Patients randomized into the interventional arm will participate in an addiction consultation during their hospital stay following LT. The participant's addiction treatment will be based on the number of risk factors identified.
- Primary Outcome Measures
Name Time Method Time to return to alcohol use During 2 years after discharge from Liver transplantation hospitalization Time to return to alcohol use is defined by the time between discharge from Liver Transplantation (LT) hospitalization and alcohol relapse,it includes either:
* Severe relapse: alcohol intake of at least 4 units per day for men and 3 per day for women for at least 100 days;
* Regular relapse: no more than 21 units a week for men, 14 units a week for women, at least 10 times a month; Alcohol consumption will be collected using the alcohol timeline follow back (TLFB), the assessor will be blinded to the participant's arm allocation.
TLFB is a calandar used to asses the participant's alcohol intake, it evaluates their daily drinking and provides a report of their drinking pattern over a given time period.
The first TLFB assessment will be carried out one month after discharge from LT hospitalization, then every 2 months up to 2 years after discharge from LT hospitalization.
- Secondary Outcome Measures
Name Time Method Return to alcohol use of the slip type During 2 years after discharge from Liver transplantation hospitalization Alcohol use will be measured using the TLFB,the assessor will be blinded to the participant's arm allocation.
Slip type is defined by a unique excessive alcohol consumption (more than 4 alcohol drinks on a single occasion).
The first TLFB assessment will be carried out one month after discharge from LT hospitalization, then every 2 months up to 2 years after discharge from LT hospitalization.Other psychoactive substances use During 2 years after discharge from Liver transplantation hospitalization Psychoactive substances use (opiates, abuse drugs, psychostimulants or psychedelics ) will be self reported by the participant during interviews with an assessor who is blinded to their arm allocation.
Psychoactive substances use assessment will be carried out one month after discharge from LT hospitalization, then every 2 months up to 2 years after discharge from LT hospitalization.Addiction therapies During 2 years after discharge from Liver transplantation hospitalization Addiction therapies (behavioral, motivational therapy and medication) implemented in the intervention arm will be described.
Major significant clinical events During 2 years after discharge from Liver transplantation hospitalization Major significant clinical events includes death, cardiovascular events (myocardial infarction, pulmonary embolism, stroke), De Novo cancer and graft rejection.
The occurrence of major significant clinical events will be collected during the participation period, time-to-event is defined as the time from LT until event or loss to follow-up or end of the study or death.Tobacco use During 2 years after discharge from Liver transplantation hospitalization Tobacco use will be measured by relative reduction in the number of cigarettes smoked per day compared with baseline, and by smoking abstinence at 24 months after discharge from LT hospitalization, for at least one month. Tobacco use will be self reported by the participant during interviews with an assessor who is blinded to their arm allocation.
Tobacco use assessment will be carried out one month after discharge from LT hospitalization, then every 2 months up to 2 years after discharge from LT hospitalization.Mortality and alcohol-associated mortality rate During 2 years after discharge from Liver transplantation hospitalization The occurrence of death (overall mortality and alcohol-associated mortality) will be collected during the participation period.
Time-to-death is defined as the time from LT until death.Biochemical liver tests During 2 years after discharge from Liver transplantation hospitalization Biochemical liver tests ( Alanine transaminase ALT, Aspartate transaminase AST, gamma-glutamyl transferase GGT, alkaline phosphatase and bilirubin) evolution will be assessed.
Biochemical liver tests will be measured as X upper limit normal ULN, 3 months after discharge from LT hospitalization, then every 2 months up to 2 years after discharge from LT hospitalization.Alcohol consumption biomarker ethanol/Peth) At 1 month, 11 or 13 months and at 24 months after discharge from Liver transplantation hospitalization Alcohol use biomarker (Phosphatidylethanol/Peth) kinetics, tested 3 times a year, will be compared to self-reported alcohol consumption.
Blood phosphatidylethanol concentration is determined by liquid chromatography coupled to a tandem mass spectrometer.Liver fibrosis 2 years after discharge from Liver transplantation hospitalization Liver fibrosis will be assessed using liver stiffness measurement by pulse elastometry (Fibroscan) and expressed in kilopascal (kPa).
Evolution of cognitive disorders During 2 years after discharge from Liver transplantation hospitalization Cognitive disorders will be measured using the Montreal Cognitive Assessment (MoCA) test which is a screening tool used to determine if there is any impairment in the participant's cognitive function, including their ability to understand, reason, and remember.
The MoCA score ranges from 0 to 30:
* 27-30: is considered normal
* 18-26: indicates the presence of mild cognitive impairment
* 10-17: indicates the presence of moderate cognitive impairment
* \< 10: indicates the presence of severe cognitive impairment
MoCA test will be carried out at inclusion, 3 months after discharge from LT hospitalization then every 2 months up to 2 years after discharge from LT hospitalization.
Trial Locations
- Locations (17)
Besançon University Hospital
🇫🇷Besançon, France
Bordeaux University Hospital
🇫🇷Bordeaux, France
Clermont Ferrand University Hospital
🇫🇷Clermont-Ferrand, France
Dijon University Hospital
🇫🇷Dijon, France
Grenoble University Hospital
🇫🇷Grenoble, France
Lille University Hospital
🇫🇷Lille, France
Lyon University Hospital
🇫🇷Lyon, France
Marseille University Hospital
🇫🇷Marseille, France
Montpellier University Hospital
🇫🇷Montpellier, France
Nice University Hospital
🇫🇷Nice, France
APHP Mondor
🇫🇷Paris, France
APHP Paul Brousse
🇫🇷Paris, France
APHP Salpetrière
🇫🇷Paris, France
Rennes University Hospital
🇫🇷Rennes, France
Strasbourg University Hospital
🇫🇷Strasbourg, France
Toulouse University Hospital
🇫🇷Toulouse, France
Tours University Hospital
🇫🇷Tours, France