Effects of Perioperative Intravenous Dexamethasone on Pain in Out Patient Knee Surgery
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Post Operative VAS Pain Scale
研究概览
简要总结
The purpose of the study is to determine the opiate sparing effects of intravenously administered dexamethasone in outpatient knee surgery. Dexamethasone is a glucocorticoid with well known antiemetic effects. However, the analgesic effects of dexamethasone have not been adequately researched. Following surgery, patients are typically discharged home with PO opiates to manage post-operative pain. The investigators believe that by using VAS (Visual Analog Scale) for Pain the investigators can show that a single dose of dexamethasone can reduce pain scales and opiate consumption post-operatively, on Post Operative Day (POD 1) when compared to placebo.
详细描述
Findings of Modest improvement in pain scores and postoperative nausea at 24 hours with Dexamethasone
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult patients undergoing ambulatory knee arthroscopy surgery
- •Must provide phone contact number and agree to phone followup on post operative day 1
排除标准
- •Patients with major systemic disease
- •Allergy or intolerance to study drug
研究组 & 干预措施
Intervention
Dexamethasone 8mg iv x 1
干预措施: Dexamethasone 8mg iv x1 (Drug)
Placebo
placebo
干预措施: placebo (Drug)
结局指标
主要结局
Post Operative VAS Pain Scale
时间窗: 24 hours
Patients were instructed to select a number between zero and ten to indicate the degree of pain they experience (zero being no pain and ten being the worst pain they could imagine). Therefore, ten is worse than zero.
次要结局
- Amount of Postop Narcotic Usage(24 hours)
- Postop Nausea(24 hours)
研究者
Lauren J. Fisher
Attending Physician
Beth Israel Deaconess Medical Center