Evaluation of effects of aqueous extract of Iranian oak (Quercus brantii) on antioxidant capacity and stress oxidative of thalassemia patients

Phase 2

• Conditions: Thalassaemia.; Beta thalassaemia; icd-56.1

• Registration Number: IRCT2016040427205N1
• Lead Sponsor: Sharekord University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Patients with thalassemia major 2. patients with regular blood transfusions 3. Patients who received chelation therapy (desferal) at least four days a week 4. 10-60 years old 5. getting informed consent
Exclusion criteria:
1. Under 10 years
2. Positive Hepatitis
3. Positive HIV
  4. heart failure and chronic kidney disease
5. peregnance
6. chelating not answer or other chelating use.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ferritin. Timepoint: Before and after of study. Method of measurement: ELIZA.;Iron. Timepoint: Before and after of study. Method of measurement: Biochemical Auto analizer.;Glutathione peroxidase. Timepoint: Before and after of study. Method of measurement: Spectrophotometric.;Catalase. Timepoint: Before and after of study. Method of measurement: Spectrophotometric.;Superoxide dismutase. Timepoint: Before and after of study. Method of measurement: Spectrophotometric.;Carbonyl protein. Timepoint: Before and after of study. Method of measurement: Spectrophotometric.;Malondialdehyde. Timepoint: Before and after of study. Method of measurement: HPLC.;Total Capacity Antioxidant. Timepoint: Before and after of study. Method of measurement: Spectrophotometric.

Secondary Outcome Measures

Name	Time	Method
Alanin Transferase. Timepoint: Before and after of study. Method of measurement: Biochemical auto analyzer.;Aspartate amino transferase. Timepoint: Before and after of study. Method of measurement: Biochemical auto analyzer.;Triglyceride. Timepoint: Before and after of study. Method of measurement: Biochemical auto analyzer.;Cholestrol. Timepoint: Before and after of study. Method of measurement: Biochemical auto analyzer.