NL-OMON47701招募中不适用
Feasibility of MRI-guided focal salvage high-dose-rate brachytherapy for locally recurrent prostate cancer - MRI-guided focal salvage HDR-BT for locally recurrent prostate cancer
niversitair Medisch Centrum Utrecht0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age >=18 years
- •- Biopsy proven local recurrence
- •- Biopsy proven recurrence at least 2 years after primary radiotherapy
- •treatment (low-dose-rate brachytherapie or external beam radiation therapy)
- •- Limited and non-aggressive tumor presentation at time of salvage (Prostate
- •Spedific Antigen (PSA) at time of salvage <10)
- •- Prostate Specific Antigen (PSA) doubling time more than 12 months
- •- Acceptable toxicity of primary radiation treatment (International Prostate
- •Symptom Score (IPSS)<15)
- •- Tumour location technically feasible for brachytherapy
- •- Tumour on MRI and PSMA-PET scan within anatomical prostate borders (no
- •extracapsular growth or metastasis)
- •- Karnofsky score >=70
- •- Written informed consent
- •- Fit for spinal anaesthesia
排除标准
- •- Distant metastasis
- •- Severe toxicity during primary radiation treatment (International Prostate
- •Symptom Score (IPSS)>15)
- •- Patients who meet exclusion criteria for MRI following the protocol of the
- •radiology department of the UMC Utrecht
- •- Anticoagulant administration continuously required, except for Ascal
- •- Discongruence between prostate biopsies and contrast MR imaging
- •- No prior prostate cancer treatment(s) (like a recent TURP (<6 months before
- •focal salvage HDR treatment), HIFU, cryosurgery), except for radiotherapy
研究者
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