Perioperative Cardiac Arrest and Outcome

Completed

• Conditions: Heart Arrest; Anesthesia

• Registration Number: NCT05316779
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

With ethical approvement, the investigators want to assess the incidence, circumstances and outcomes of patients with perioperative cardiac arrests over a period of 8 years.

Currently, there is little data and information about a cardiovascular arrests during anesthesia. Little is also known about the health-related quality of life afterwards. In the investigators research project, the investigators want to find out if there are, for example, specific factors that cause cardiovascular arrests and factors that can improve the chances of survival after a cardiovascular arrest. The investigators are also looking for possible factors and measurements that can minimize or even prevent future events during anesthesia.

Detailed Description

A perioperative cardiac arrest is a special form of in-hospital cardiac arrest. It was claimed that perioperative cardiac arrests are under-investigated. The spare existing data suggest incidences of perioperative cardiac arrest to be between 0.5 - 3 per 10.000 for adult patients and 2 - 10 per 10.000 for paediatric patients. Data on circumstances, predictors and outcomes of perioperative cardiac arrest are rare, especially for paediatric patients. Some reports suggest that incidence is negatively associated with a country's higher development. As no Swiss data is available on this topic, this retrospective audit aims to bridge the knowledge gap and finally intends to make clinicians aware of potential risks or contributing factors of survival, which might raise safety for all patients undergoing procedures under anaesthesia.

The investigators will include all patients of all ages with a perioperative cardiac arrest at Bern University Hospital from 1st January 2015 until 31st December 2021 (7 year observational period).

Study Timeline

• Study First Submitted: 2022-03-21
• Study First Submitted QC: 2022-03-30
• Study First Posted: 2022-04-07
• Study Start: 2022-04-14
• Primary Completion: 2023-09-26
• Status Verified: 2023-10
• Study Completion: 2023-10-25
• Last Update Submitted: 2023-10-26
• Last Update Posted: 2023-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

Not provided

Exclusion Criteria

• A perioperative cardiac arrest before 1st January 2015 or after 31st December 2021
• <5 chest compressions (direct, mechanical or extracorporeal Cardiopulmonary Resuscitation (CPR))
• All in-hospital cardiac arrests, that occur without being under anaesthesia care
• Patients already admitted to a hospital with a cardiac arrest (out-of hospital cardiac arrests)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Return of spontaneous circulation (ROSC)	60 minutes	Number of patients with a Return of spontaneous circulation (ROSC) during resuscitation

Secondary Outcome Measures

Name	Time	Method
Sustained ROSC	60 minutes	Number of patients with a Return of spontaneous circulation during resuscitation over 20 minutes
Survival post-anaesthesia care unit or intensive care unit	24 hours	Number of patients with a Survival to post-anaesthesia care unit (PACU) or intensive care unit (ICU)
SF-12 after hospital discharge	1 month	Health-related quality of life according (HRQOL) the Short Form Survey (SF-12) after hospital discharge
Survival to hospital discharge	4 weeks	Number of patients with a Survival to hospital discharge
CPC after hospital discharge	1 month	Neurological status according Clinical Performance Category (CPC) after hospital discharge
SF-12 3 month after cardiac arrest	3 months	Health-related quality of life (HRQOL) according the Short Form Survey (SF-12) at 3 months after the peri-operative cardiac arrest
CPC 3 month after cardiac arrest	3 months	Neurological status according Clinical Performance Category (CPC) at 3 months after the peri-operative cardiac arrest

Trial Locations

Locations (1)

University Hospital Bern; 🇨🇭 Bern, Switzerland