Sequential Enhanced Safety Study of a Novel Coronavirus mRNA Vaccine in Adults Aged 18 Years and Older Who Have Completed 3 Doses of a New Inactivated Coronavirus Vaccine.
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- Evaluation of the incidence of adverse reactions (AR) in all subjects within 28 days of exemption
研究概览
简要总结
This trial is a clinical study to evaluate the safety of sequential boosters of novel coronavirus mRNA vaccine in adults aged 18 years and older who have completed three doses of novel inactivated coronavirus vaccination. According to the results of the previous phase I clinical trial, the incidence of adverse reactions in the 0.3 ml dose group was lower than that in the 0.5 ml dose group, and the degree of adverse reactions was weaker. The dose of 0.3ml was chosen for the current study, and a 1-dose immunization program was completed for safety observation.
详细描述
According to the results of the preliminary phase I clinical trial, the incidence of adverse reactions in subjects in the 0.3 ml dose group was lower than in the 0.5 ml dose group and the degree of adverse reactions was weaker. The dose of 0.3ml was chosen for the current study.
The trial was designed to enroll 800 adult subjects aged 18 years and older who had completed three doses of inactivated New Coronavirus vaccine with an interval of more than 6 months between doses, and the proportion of elderly people aged 60 years and older was approximately 20%. Subjects will receive 0.3 ml of mRNA vaccine, complete a 1-dose immunization program, and undergo safety observations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years old and above adults.
- •Able and willing to comply with the requirements of the clinical trial protocol and able to sign the informed consent form.
- •Willing to discuss medical history with the investigator or physician and allow access to all medical records related to this trial.
- •Subjects have completed 3 doses of inactivated vaccine with at least 6 months between the last dose.
排除标准
- •Subject is unfit to participate in the study based on the investigator's judgment.
- •History of Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome(SARS) or other coronavirus infection or disease or history of related immunizations.
- •Prior history of severe allergic reactions or hypersensitivity to vaccines or drugs, such as urticaria, severe skin eczema, dyspnea, laryngeal edema, hemangioma, etc., or history of serious adverse reactions associated with vaccines and/or history of severe anaphylactic reactions (e.g., systemic allergic reactions) to any component of the study vaccine.
- •Immunocompromised individuals with known or suspected immunodeficiency as determined by medical history and/or physical examination, inability to control autoimmune disease, etc.
- •Bleeding constitutional or condition associated with prolonged bleeding, which the investigator believes is contraindicated by intramuscular injection.
- •Positive urine pregnancy test or lactating women, volunteers or their partners who have plans to become pregnant within 6 months.
- •Severe hypertension and uncontrolled by medication (at the time of field measurement: systolic blood pressure ≥ 160 mmHg and diastolic blood pressure ≥ 100 mmHg).
- •Suffering from a serious chronic disease or in a progressive stage that cannot be controlled smoothly, such as severe diabetes mellitus, thyroid disease, etc.
- •Previously suffering from serious cardiac diseases such as myocarditis and pericarditis.
- •Those who have planned to receive other vaccines within 28 days before or after the trial vaccination.
- •Those receiving immunosuppressive therapy, including cytotoxic drugs or systemic corticosteroids, such as treatment for cancer or autoimmune disease, or are scheduled to receive treatment throughout the study period. If systemic corticosteroids are used for a short period of time (<14 days) for the treatment of an acute disease, subjects should not be allowed to enter this study until at least 28 days after corticosteroid therapy has ceased prior to study vaccination. Inhalation/spray, intra-articular, intra-bone, or topical (skin or eye) corticosteroid use is permitted.
- •Have received or plan to receive blood/plasma products or immunoglobulins throughout the study period 60 days prior to study inoculation.
- •Participated in other studies involving interventional studies within 28 days prior to study entry and/or during study participation.
- •Have participated in other interventional studies involving lipid-containing nanoparticles.
- •Have suspected COVID-19 symptoms such as respiratory symptoms, fever, cough, shortness of breath, and dyspnea.
- •Axillary temperature >37.0°C or use of over-the-counter medications such as antipyretics and analgesics (e.g. acetaminophen, ibuprofen, naproxen, etc.) within 12 hours prior to experimental vaccination.
结局指标
主要结局
Evaluation of the incidence of adverse reactions (AR) in all subjects within 28 days of exemption
时间窗: 28 days post vaccination
Incidence of adverse reaction (AR)
Evaluation of the incidence of Serious Adverse Event (SAE) and Adverse Event of Special Interest (AESI) in all subjects at 6 months after exemption
时间窗: 6 months post vaccination
Incidence of Serious Adverse Event (SAE) and Adverse Event of Special Interest (AESI)
次要结局
- Evaluation of the incidence of adverse events in all subjects within 28 days of exemption(28 days post vaccination)
- Evaluation of the incidence of adverse reactions in all subjects at 30 minutes post-dispensing(30 minutes post vaccination)
研究者
Yu Qin
Director Technician
West China Second University Hospital