Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia for Lower Abdominal Surgery
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Duration of analgesia
研究概览
简要总结
The aim of this work is to compare the hemodynamic and analgesic properties of Dexmedetomidine and Magnesium sulphate infusion in lower abdominal surgery.
详细描述
Dexmedetomidine is a relatively new alpha 2 adrenergic receptor agonist with a higher α2/α1 selectivity ratio of 1620:1 that provides analgesic and anesthetic effects . Dexmedetomidine has various clinical uses in anesthesia such as sedation, and prolongation of the duration of postoperative analgesia when used as an adjuvant through intrathecal, epidural, or intravenous routes.
Magnesium sulphate is another commonly used drug in anesthesia. Magnesium sulphate suppresses nociceptive impulses through inhibition of voltage-gated calcium channels and through antagonism of the N-methyl D-aspartate (NMDA) receptors.
Although both drugs were reported to prolong the duration of spinal anesthesia, no studies to the best of our knowledge had compared the analgesic and hemodynamic profile of both drugs when used as intravenously during spinal anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients aged between 18 and 65 years.
- •Scheduled for lower abdominal surgery.
排除标准
- •Systolic blood pressure less than 100 mmHg
- •Coagulation disorders
- •History of heart failure
- •Mitral or Aortic stenosis
研究组 & 干预措施
Saline group
This group will receive normal saline infusion
干预措施: Normal saline (Drug)
Dexmedetomidine group
This group will receive dexmedetomidine infusion at a rate of 0.5 mcg/kg/hour
干预措施: Dexmedetomidine (Drug)
Magnesium Sulphate group
This group will receive Magnesium Sulphate infusion at a rate of 15 mg/Kg/hour
干预措施: Magnesium Sulphate (Drug)
结局指标
主要结局
Duration of analgesia
时间窗: 24 hours
Duration of analgesia after the operation defined as the time till the first analgesic request by the patient
次要结局
- Systolic blood pressure(6 hours)
- Heart rate(6 hours)
- Duration of motor block(12 hours)
- Diastolic blood pressure(6 hours)
- Onset of sensory block(30 minutes after spinal anesthesia)
- Onset of motor block(30 minutes after spinal anesthesia)
- Ramsay Sedation Scale(12 hours after spinal anesthesia)
研究者
Ahmed Hasanin
Assistant professor
Cairo University