Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Blood test characteristics
研究概览
简要总结
The diaphragm is the fundamental muscle of the respiratory system. The diaphragmatic dysfunction is present in 60% of critical patients at hospital admission and up to 80% after prolonged mechanical ventilation and difficult weaning.
Risk factors associated with diaphragm dysfunction and atrophy are sepsis, trauma, sedatives, steroids, and muscle relaxants.
The main pathology characteristics of diaphragm biopsies of mechanically ventilated patients are atrophy and a reduction in contractility, determining an impact on the clinical outcome.
Shi et al. found a higher section area of the diaphragm muscle fiber in biopsies of post mortem COVID-19 patients versus negative patients, independently from days of mechanical ventilation.
The hypothesis of our study is to identify different clusters of pathological presentation in post-mortem COVID-19 mechanically ventilated patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients deceased in the intensive care unit positive to SARS-CoV-2 and mechanically ventilated
- •post-mortem examination of the diaphragm
排除标准
- •patients with a terminal disease and a prognosis of less than 48 hours at admission.
结局指标
主要结局
Blood test characteristics
时间窗: One week post mortem
Evaluate if there are specific clusters in the study population and find different blood test characteristics.
Pathology characteristics
时间窗: One week post mortem
Evaluate if there are specific clusters in the study population and find different pathology characteristics.
Clinical characteristics
时间窗: One week post mortem
Evaluate if there are specific clusters in the study population and find different clinical characteristics.
次要结局
- Mechanical ventilation(One week post mortem)
- Arterial blood gas analysis(One week post mortem)
- Therapy(One week post mortem)
研究者
Luigi Vetrugno
Professor in Anesthesia and Intensive Care
Azienda Sanitaria-Universitaria Integrata di Udine