Identifying Factors Influencing In-Hospital Relapse in Pemphigus Patients
- Conditions
- Pemphigus Vulgaris
- Registration Number
- NCT06167408
- Lead Sponsor
- First Affiliated Hospital of Chongqing Medical University
- Brief Summary
The objective of this retrospective study was to investigate the factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins. The study included 96 pemphigus patients hospitalized in China between January 2014 and December 2020. The primary questions addressed by the study were:
What are the risk factors associated with in-hospital relapse during acute episodes of pemphigus? Participants in the study underwent a retrospective analysis using univariate and multivariate Cox regression analysis to identify and understand the various risk factors contributing to in-hospital relapse. This research aimed to contribute valuable insights into the factors influencing the course of pemphigus, providing crucial information for better management and treatment strategies.
- Detailed Description
This retrospective study conducted in China between January 2014 and December 2020 aimed to comprehensively examine factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins-essential cell adhesion molecules. The study enrolled 96 pemphigus patients who were hospitalized during acute episodes.
Research Questions:
Primary Question:
What are the identifiable risk factors associated with in-hospital relapse in pemphigus patients during acute episodes?
Methods:
Study Type: Retrospective Observational Study Participant Population: 96 pemphigus patients hospitalized in China Duration: January 2014 to December 2020
Main Tasks:
Data Collection:
Retrospective analysis of medical records and clinical data of pemphigus patients during acute hospitalizations.
Identification of demographic information, clinical characteristics, and treatment modalities.
Risk Factor Determination:
Univariate and multivariate Cox regression analysis employed to assess potential risk factors.
Variables considered included demographic factors, disease severity, and specific treatment regimens.
Outcome Measurement:
Identification of in-hospital relapse as the primary outcome. Correlation of relapse occurrence with the identified risk factors.
Results:
Key Findings:
Identification of specific risk factors contributing to in-hospital relapse in pemphigus patients.
Quantification of the impact of demographic and clinical variables on relapse probability.
Significance:
Clinical Implications:
Contribution of valuable insights for clinicians in predicting and managing in-hospital relapse in pemphigus patients.
Informing treatment strategies based on identified risk factors.
Research Contribution:
Expansion of understanding regarding the course and management of pemphigus. Providing a foundation for future prospective studies and the development of targeted interventions.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
- inpatients.
- Pathologic diagnosis of pemphigus.
- Patients hospitalized for cyclophosphamide shock therapy only.
- Patients who did not recover and were discharged due to personal reasons.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method in-hospitalization relapse through hospitalization (Up to 1 month) the occurrence of in-hospital relapse among pemphigus patients during acute episodes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
First Affiliated hospital of Chongqing Medical University
🇨🇳Chongqing, Yuzhong District, China