Maintenance antidepressants versus treatment cessation in the prevention of depression recurrence.

Not Applicable

Completed

• Conditions: Depression; Mental Health - Depression

• Registration Number: ACTRN12608000613303
• Lead Sponsor: Health Research Council of NZ

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-12-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 330

Inclusion Criteria

Aged between 18 and 75 years
Living in the Christchurch, Wellington or Auckland urban areas
Historical diagnosis of unipolar depressive disorder for which current therapy is maintenance antidepressants
Diagnosed and treated for depression in primary care
On treatment with antidepressants for at least 12 months
Currently in remission: Montgomery Asberg Depression Rating Scale (MADRS)
Patient willing to try discontinuation

Exclusion Criteria

Diagnosis / treatment carried out in secondary care setting (inpatient or outpatient referral to psychiatrist) for the index episode
Unipolar depression not primary reason for prescription of SSRI
Bipolar disorder
Psychotic disorder
Substance dependence disorder
Postnatal depression in the last 12 months
Pregnancy
Serious current suicide risk (score >2 on MADRS suicide item)
English language skills inadequate to understand and respond to rating scales
Concurrent use of any other antidepressant

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression recurrence. Recurrence will be assessed using the interviewer administered Montgomery Asberg Depression Rating Scale (MADRS).[This will be assessed at week 1,2 and 4 and then at 3 monthly time points during the 18 months of follow up]