Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies

Not Applicable

Completed

• Conditions: Benzodiazepines Therapeutic Use

• Registration Number: NCT00268775
• Lead Sponsor: Radboud University Medical Center

Brief Summary

The purpose of this study is to compare the effect of two implementation strategies for a simple patient-directed intervention to reduce long-term benzodiazepine use in Dutch community pharmacies.

Detailed Description

In Dutch community pharmacies many projects have been undertaken in the field of pharmaceutical care, with mixed results. It is not yet clear which elements exactly contribute to the success of these projects and to implementation of pharmaceutical care.

One of the subjects to which attention is paid in community pharmacies, is the undesirable long-term use of benzodiazepines. Treatment methods for discontinuation of long-term benzodiazepine use have been studied rather extensively. A simple patient-directed discontinuation letter proved to be effective in several studies.

Comparison: a minimal intervention group (pharmacists carrying out the intervention guided by a manual only) compared to a maximal intervention group (pharmacists receiving a manual, a training aimed at better cooperation and communication with family practitioners and some support in the management of the project).

Study Timeline

• Study Start: 2005-11
• Study First Submitted: 2005-12-21
• Study First Submitted QC: 2005-12-21
• Study First Posted: 2005-12-22
• Primary Completion: 2006-12
• Study Completion: 2006-12
• Status Verified: 2009-08
• Last Update Submitted: 2009-08-17
• Last Update Posted: 2009-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20000

Inclusion Criteria

• benzodiazepine use for more than 3 months in the last 12 months AND for more than 60 days in the last 2 months

Exclusion Criteria

• treatment by psychiatrist, treatment of alcohol- or drug misuse, psychotic episodes in history, epilepsy, terminal disease, not mastering the Dutch language, individual criteria used by the family practitioner

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
percentage of general practitioners that reviewed and returned the list of longterm users.
percentage of letters sent by the pharmacists in the four months after receiving the manual.
percentage of long-term benzodiazepine users that managed to quit or significantly reduce their use in months 0-3, 4-6 and 10-12 after receiving the letter.

Secondary Outcome Measures

Name	Time	Method
evaluation of the implementation strategies

Trial Locations

Locations (90)

Apotheek Wijchen-Zuid; 🇳🇱 Wijchen, Netherlands

Apotheek de Schakel; 🇳🇱 Best, Netherlands

Apotheek Heivelden; 🇳🇱 Best, Netherlands

Apotheek Koolen-Motké; 🇳🇱 Deurne, Netherlands

Apotheek de Schelde; 🇳🇱 Deurne, Netherlands

Apotheek Elsloo; 🇳🇱 Elsloo, Netherlands

Apotheek Ewijk; 🇳🇱 Ewijk, Netherlands

Apotheek Brouwhuis; 🇳🇱 Helmond, Netherlands

Apotheek Eygelshoven; 🇳🇱 Eygelshoven, Netherlands

Lloyds Apotheek Geldrop; 🇳🇱 Geldrop, Netherlands

Kring-apotheek de Rijpel; 🇳🇱 Helmond, Netherlands

Apotheek het Frans Brugske; 🇳🇱 Gemert, Netherlands

Apotheek Gennep; 🇳🇱 Gennep, Netherlands

Apotheek de Pijlers; 🇳🇱 Goes, Netherlands

Zeeuwse Apotheek; 🇳🇱 Goes, Netherlands

Apotheek de Goese Polder; 🇳🇱 Goes, Netherlands

Apotheek de Luifel; 🇳🇱 Helmond, Netherlands

Apotheek Landgraaf; 🇳🇱 Landgraaf, Netherlands

Apotheek Nieuwenhagen; 🇳🇱 Landgraaf, Netherlands

Apotheek Maasdorpen; 🇳🇱 Meerlo, Netherlands

Lloyds Apotheek de Roerstreek; 🇳🇱 Melick, Netherlands

Apotheek Ringeling; 🇳🇱 Middelburg, Netherlands

Apotheek Hummelen; 🇳🇱 Middelburg, Netherlands

Apotheek Welsinge; 🇳🇱 Middelburg, Netherlands

Kring-apotheek Beckers; 🇳🇱 Nijmegen, Netherlands

Apotheek van der Ploeg; 🇳🇱 Nijmegen, Netherlands

Apotheek Reusel; 🇳🇱 Reusel, Netherlands

Apotheek Souburg; 🇳🇱 Oost-Souburg, Netherlands

Lloyds Apotheek Postert; 🇳🇱 Posterholt, Netherlands

Lloyds Apotheek Clemens-Haan; 🇳🇱 Roermond, Netherlands

Apotheek Hendrickx-Maasniel; 🇳🇱 Roermond, Netherlands

Apotheek Roermond Zuid; 🇳🇱 Roermond, Netherlands

Apotheek Rosmalen-Walschot; 🇳🇱 Rosmalen, Netherlands

apotheek Simpelveld-Bocholtz; 🇳🇱 Simpelveld, Netherlands

Apotheek Hopveld; 🇳🇱 Sint Michielsgestel, Netherlands

Apotheek de Belleman; 🇳🇱 Valkenswaard, Netherlands

Apotheek Valkenswaard; 🇳🇱 Valkenswaard, Netherlands

Apotheek Vlaslant; 🇳🇱 Valkenswaard, Netherlands

Apotheek Dommeldal; 🇳🇱 Valkenswaard, Netherlands

apotheek 't Zuid; 🇳🇱 Veghel, Netherlands

Veldhovense Apotheek; 🇳🇱 Veldhoven, Netherlands

Apotheek Zonderwijk; 🇳🇱 Veldhoven, Netherlands

Apotheek Dr. H. Kilian; 🇳🇱 Wijchen, Netherlands

Apotheek de Duivenakker; 🇳🇱 Gennep, Netherlands

Apotheek Rosmalen; 🇳🇱 Rosmalen, Netherlands

Apotheek de Baandert; 🇳🇱 Sittard, Netherlands

Apotheek Bakel-Milheeze; 🇳🇱 Bakel, Netherlands

Kring-apotheek Bergeyk; 🇳🇱 Bergeyk, Netherlands

Apotheek Blanckenburgh; 🇳🇱 Beuningen, Netherlands

Apotheek van de Wouw; 🇳🇱 Brunssum, Netherlands

Apotheek Budel; 🇳🇱 Budel, Netherlands

Apotheek Schellekens; 🇳🇱 Den Bosch, Netherlands

Reinald apotheek; 🇳🇱 Roermond, Netherlands

Apotheek Berlicum; 🇳🇱 Berlicum, Netherlands

Lloyds Apotheek van Kollenburg; 🇳🇱 Best, Netherlands

Apotheek Bocholtz; 🇳🇱 Bocholtz, Netherlands

Apotheek Cleij; 🇳🇱 Den Bosch, Netherlands

Apotheek Empel; 🇳🇱 Den Bosch, Netherlands

Apotheek in 't Groen; 🇳🇱 Deurne, Netherlands

Apotheek Druten; 🇳🇱 Druten, Netherlands

Apotheek de Kempen; 🇳🇱 Eersel, Netherlands

Apotheek Lindner; 🇳🇱 Gemert, Netherlands

Linde apotheek; 🇳🇱 Hapert, Netherlands

Service apotheek Vondellaan; 🇳🇱 Helmond, Netherlands

Apotheek Asten; 🇳🇱 Asten, Netherlands

Apotheek Groesbeek; 🇳🇱 Groesbeek, Netherlands

Apotheek Heeswijk-Dinther; 🇳🇱 Heeswijk-Dinther, Netherlands

Apotheek Stromenwijk 't Zand; 🇳🇱 Middelburg, Netherlands

Apotheek Dauwendaele; 🇳🇱 Middelburg, Netherlands

Lloyds Apotheek Donderberg; 🇳🇱 Roermond, Netherlands

Apotheek van Poppel; 🇳🇱 Wijchen, Netherlands

Apotheek Bladel; 🇳🇱 Bladel, Netherlands

Apotheek Tendijck; 🇳🇱 Helmond, Netherlands

Service Apotheek de Bus; 🇳🇱 Helmond, Netherlands

Lloyds Apotheek Herkenbosch; 🇳🇱 Herkenbosch, Netherlands

Apotheek Hegtermans; 🇳🇱 Herten, Netherlands

apotheek Kerkrade-centrum; 🇳🇱 Kerkrade, Netherlands

Apotheek Herten-Merum; 🇳🇱 Herten, Netherlands

Apotheek Bleijerheide; 🇳🇱 Kerkrade, Netherlands

Apotheek Schaesberg; 🇳🇱 Landgraaf, Netherlands

Apotheek MC Putstraat; 🇳🇱 Landgraaf, Netherlands

Apotheek Schonefeld; 🇳🇱 Kerkrade, Netherlands

Apotheek Medische Centrum West Kerkrade; 🇳🇱 Kerkrade, Netherlands

Apotheek Terwinselen; 🇳🇱 Kerkrade, Netherlands

Apotheek Waubach; 🇳🇱 Landgraaf, Netherlands

Apotheek Maarheeze; 🇳🇱 Maarheeze, Netherlands

Apotheek Craveld; 🇳🇱 Maasbracht, Netherlands

Apotheek Maasbracht; 🇳🇱 Maasbracht, Netherlands

Service apotheek Malden; 🇳🇱 Malden, Netherlands

Wandelbos Apotheek; 🇳🇱 Tilburg, Netherlands