Ranitidine bismuth citrate pretreatment in H. pylori eradicatio

Not Applicable

Terminated

Conditions: Diseases of the digestive system

Registration Number: KCT0005871

Lead Sponsor: Kyung Hee University Hospital at Gangdong

Brief Summary: Overall, the H. pylori eradication rate was 73.7% (73/99). Success rates of H. pylori eradication were 80.9% and 67.3% in the RBC pretreatment and control groups, respectively, as only 9 (19.1%) of the 47 subjects in the RBC pretreatment group and 17 (32.7%) in the triple standard regimen group demonstrated eradication failure (Fig 2). As our trial was discontinued earlier than planned, the H. pylori eradication rate failed to attain statistical significance between the pretreatment and control groups (p = 0.126). No significant differences were observed between the success and failure groups of H. pylori eradication in terms of age, sex, alcohol consumption, smoking, exercise pattern, presence of comorbidity, or aspirin use.

Detailed Description: Not available

Recruitment & Eligibility

Status: Terminated

Sex: All

Target Recruitment: 114

Inclusion Criteria

? Patients were eligible if aged between 20 and 70 years
? Patients confirmed presenting H. pylori infection within one year and did not treat H. pylori eradication (include H. pylori-induced gastritis regardless of gastric ulcer)
? Patients received comprehensive information regarding the study, with informed consent obtained before the initiation of any study-related processes

Exclusion Criteria

? Patients who used less than two weeks before the screening visit following as
i.PPIs and H2-receptor antagonist
ii.Antibiotics including clarithromycin, amoxicillin, metronidazole, and tetracycline
iii.Bismuth compound, mucosal protects
iv.Corticosteroid
v.Food product relating to gastric function
? Patients who used drugs metabolized by CYP450 becuase cimetidine strongly suppress and increases concentration of drug in serum
i. Warfarin
ii. Diazepam
iii. Propranolol
iv. Erythromycin
? a previous gastric malignancy
? Previous gastric operation
? Comorbidity
i.Dialysis
ii.Diet with restrictive potassium
iii.Uncontrolled nephropathy or hepatic disease
?Alalarming signs (e.g., abnormal weight loss, hematochezia, anemia, or significant bowel habit changes)
?pregnant, planning to pregnancy or breastfeeding
?drug users or alcoholics
?Inappropriate candidate according to researchers' judgement