KCT0005871终止未知
Influence of pretreatment with ranitidine bismuth citrate on the cure rates of Helicobacter pylori eradication
适应症
试验速览
- 阶段
- 未知
- 状态
- 终止
- 入组人数
- 114
研究概览
简要总结
Overall, the H. pylori eradication rate was 73.7% (73/99). Success rates of H. pylori eradication were 80.9% and 67.3% in the RBC pretreatment and control groups, respectively, as only 9 (19.1%) of the 47 subjects in the RBC pretreatment group and 17 (32.7%) in the triple standard regimen group demonstrated eradication failure (Fig 2). As our trial was discontinued earlier than planned, the H. pylori eradication rate failed to attain statistical significance between the pretreatment and control groups (p = 0.126). No significant differences were observed between the success and failure groups of H. pylori eradication in terms of age, sex, alcohol consumption, smoking, exercise pattern, presence of comorbidity, or aspirin use.
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 20(Year) 至 70(Year)（—）
- 性别
- All
入选标准
- •? Patients were eligible if aged between 20 and 70 years
- •? Patients confirmed presenting H. pylori infection within one year and did not treat H. pylori eradication (include H. pylori-induced gastritis regardless of gastric ulcer)
- •? Patients received comprehensive information regarding the study, with informed consent obtained before the initiation of any study-related processes
排除标准
- •? Patients who used less than two weeks before the screening visit following as
- •i.PPIs and H2-receptor antagonist
- •ii.Antibiotics including clarithromycin, amoxicillin, metronidazole, and tetracycline
- •iii.Bismuth compound, mucosal protects
- •iv.Corticosteroid
- •v.Food product relating to gastric function
- •? Patients who used drugs metabolized by CYP450 becuase cimetidine strongly suppress and increases concentration of drug in serum
- •i. Warfarin
- •ii. Diazepam
- •iii. Propranolol
- •iv. Erythromycin
- •? a previous gastric malignancy
- •? Previous gastric operation
- •? Comorbidity
- •ii.Diet with restrictive potassium
- •iii.Uncontrolled nephropathy or hepatic disease
- •?Alalarming signs (e.g., abnormal weight loss, hematochezia, anemia, or significant bowel habit changes)
- •?pregnant, planning to pregnancy or breastfeeding
- •?drug users or alcoholics
- •?Inappropriate candidate according to researchers' judgement
研究者
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