Comparison of the effect of gabapentin and oral pregabalin on spinal anesthesia

Phase 2

• Conditions: Spinal anesthesia.; Spinal and epidural anesthesia-induced headache during the puerperium; O89.4

• Registration Number: IRCT20200918048748N1
• Lead Sponsor: Kashan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 November 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

Being at the age of 18-70 years
ASA class 1-2
undergoing orthopedic elective surgery with spinal anesthesia below the T10 level
Duration of surgery less than 2 hours

Exclusion Criteria

Weight less than 40 kg
Hypersensitivity to pregabalin
Hypersensitivity to the drug gabapentin
Allergy to bupivacaine
Localized sepsis at the injection site of the spinal needle
Pregnancy and lactation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative nausea and vomiting. Timepoint: They are measured and recorded every 5 minutes until the end of the operation and every 15 minutes in recovery for up to two hours. Method of measurement: The incidence and severity of postoperative nausea and vomiting are assessed based on the simplified criterion of postoperative nausea and vomiting (PONV scale).;Sensory block start time. Timepoint: It is measured and recorded every 5 minutes until the end of the operation and every 15 minutes in recovery for up to two hours. Method of measurement: Based on the Visual Analogue Scale and recorded in the checklist.;Duration of anesthesia. Timepoint: It is measured and recorded every 5 minutes until the end of the operation and every 15 minutes in recovery for up to two hours. Method of measurement: Based on the Visual Analogue Scale and recorded in the checklist.