The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Change in Quadriceps muscle volume
研究概览
简要总结
In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions). Before and after training, muscle volume is measured by MRI, and muscle strength is assessed by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus lateralis to study gene and protein expression of markers regulating muscle protein turnover and prostaglandin synthesis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Considered healthy
- •Moderately trained
- •18-35 yrs
排除标准
- •Cardiovascular disease
- •Impaired kidney or liver function
- •Lower limb injury
- •Pregnancy
- •Ulcer or gastrointestinal upsets
- •Previous reactions to use of NSAID
研究组 & 干预措施
Ibuprofen
Resistance exercise 20 sessions during 8 weeks Daily consumption of 1200 mg ibuprofen (400 mg x 3) during 8 weeks
干预措施: Ibuprofen (Drug)
Acetylsalicylic acid
Resistance exercise 20 sessions during 8 weeks Daily consumption of 75 mg acetylsalicylic acid (75 mg x 1) during 8 weeks
干预措施: Acetylsalicylic acid (Drug)
结局指标
主要结局
Change in Quadriceps muscle volume
时间窗: Baseline and after 8 weeks training
Measured through MRI
次要结局
- Change in muscle protein expression(Baseline, 4 weeks and after 8 weeks training)
- Change in muscle gene expression(Baseline, 4 weeks and after 8 weeks training)
- Change in Quadriceps muscle strength(Baseline and after 8 weeks training)
研究者
Tommy Lundberg
PhD
Karolinska Institutet