The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer
Not Applicable
Completed
- Conditions
- Thyroid Cancer
- Registration Number
- NCT01833650
- Lead Sponsor
- Cyprus University of Technology
- Brief Summary
The purpose of this study is to determine whether the use of honey mouthwashes in the prevention of salivary side effects of 131I (radioiodine) therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- >18 years old
- They had a histological diagnosis of papillary, follicular, medullary or anaplastic thyroid cancer
- They had undergone total thyroidectomy
- They were able to provide consent
Exclusion Criteria
- patients who had distant metastases,
- a history of salivary-gland disorders,
- collagen tissue disease
- diabetes mellitus,
- previous radioiodine therapy or external radiation to the head or neck
- allergy to the honey
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Primary Outcome Measures
Name Time Method Grade of sialadenitis Change from Baseline grade of sialadenitis at 6 and 24 months
- Secondary Outcome Measures
Name Time Method Grade of Xerostomia Change from Baseline grade of xerostomia at 6 and 24 months Level of Health related quality of life Change from Baseline level of health related quality of life at 6 and 24 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does thymus honey utilize to protect salivary glands from 131I-induced damage in thyroid cancer patients?
How does the effectiveness of thymus honey mouthwash compare to standard-of-care sialogogues in mitigating xerostomia after radioiodine therapy?
Are there specific biomarkers that identify thyroid cancer patients most likely to benefit from thymus honey interventions post-radioiodine treatment?
What are the potential adverse events associated with thymus honey mouthwash use in radioiodine therapy for thyroid cancer and how can they be managed?
How do thymus honey mouthwashes compare to other natural compounds like licorice root or aloe vera in preventing salivary gland toxicity from 131I therapy?
Trial Locations
- Locations (1)
Bank of Cyprus Oncology
🇨🇾Nicosia, Cyprus
Bank of Cyprus Oncology🇨🇾Nicosia, Cyprus