A Prospective Randomised Trial of Two Tidal Volume Ventilator Strategies in Patients Undergoing Major Surgery

Phase 4

Completed

• Conditions: Effects of ventilation in patients undergoing major surgery; Anaesthesiology - Anaesthetics; Surgery - Other surgery; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12614000790640
• Lead Sponsor: Departments of Intensive Care and Anaesthesia, Austin Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-07-24
• Study Completion: 2018-12-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1240

Inclusion Criteria

Patients will be eligible to participate in this study if:
1. The patient is aged 40 years or older
2. The treating anaesthetist expects that the patient will remain intubated for a period of equal to or greater than two hours
3. The patient will have an arterial line inserted for routine monitoring of blood pressure during the surgical procedure

Exclusion Criteria

Patients will be ineligible for participation if:
1. The patient is pregnant and/or lactating
2. The patient has planned thoracic surgery
3. The patient has planned cardiac surgery
4. The patient has planned intracranial neurosurgery
5. Previously enrolment in this Trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of patients with a postoperative pulmonary complication. Pulmonary complications include pneumonia, bronchospasm, atelectasis, pulmonary congestion, pulmonary embolism, respiratory failure and requirements for mechanical ventilation, pleural effusion and pneumothorax. [Within the first 7 days after surgery]