A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF VARADI KASHAYA AND MUSTADI KWATHA IN THE MANAGEMENT OF STHAULYA W.S.R OVERWEIGHT CHILDREN:AN OPEN LABEL RANDOMIZED TRIAL.A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF VARADI KASHAYA AND M

BRIEF SUMMARY ON PURPOSE - Childhood Obesity:

• Overweight and obesity in children occur due to various causes.
• The most common cause is an imbalance between calories consumed and calories expended.
• Global Challenge: Childhood obesity is one of the most pressing public health challenges of the 21st century.
• It is a global issue, particularly affecting low- and middle-income countries, especially in urban areas.
• Allopathic Medication for Weight Control: Medication for weight control should be accompanied by realistic goals.
• Initial weight loss can be achieved, but medications only work while being taken; discontinuation may lead to weight regain.
• Ayurvedic Perspective on Obesity (Sthaulya):
• Sthaulya (obesity) in Ayurveda is caused by the consumption of Kapha-increasing diet and lifestyle (Ahara and Vihara), leading to impaired Jatharagni (digestive fire) and the formation of Ama (toxins).
• This also impairs Medodhatvagni (fat metabolism).
• Ayurvedic Treatment Approach: A drug for obesity should possess properties like Deepana (appetizing), Pachana (digestive), Kapha-Vata Shamana (balancing Kapha and Vata), Srotoshodhana (clearing channels), and Medonashaka (fat-reducing).
• Study Drugs:
• Varadi Kashaya: Taken from Sahasram Yogakashya Prakarana 63/10; ingredients include Haritaki, Amalaki, Bibhitaki, Chitrak, Nisha, Asana.
• Mustadi Kwatha: Taken from Charaka Samhita Sutra Sthana Chapter 23/12-14; ingredients include Musta, Aragwadh, Patha, Amalaki, Haritaki, Vibhitaka, Devdaru, Gokhshur, Khadir, Nimba, Haridra, Daruharidra, Kutaj.

BACKGROUND OF TRIAL

• Childhood Obesity: A global issue due to an imbalance between calorie intake and energy expenditure, leading to health risks like diabetes and cardiovascular disease.
• Allopathic Treatment: Short-term weight loss but with side effects like high blood pressure, and weight often returns after discontinuing medication.
• Ayurvedic Perspective: Obesity (Sthaulya) results from a Kapha-increasing diet and lifestyle, leading to impaired metabolism and toxin buildup (Ama).
• Ayurvedic Treatment: Focuses on balancing metabolism using natural remedies that are safer and more cost-effective than allopathic treatments.
• Study Objective: To compare the efficacy of Varadi Kashaya and Mustadi Kwatha, two Ayurvedic formulations, in managing obesity in overweight children.
• Significance: Offers a natural, long-term alternative to managing childhood obesity without harmful side effects.
• PRIMARY FINDING - Reduce in BMI and weight of the children as per the age along with prevention of comorbidity of childhood nutritional obesity. SECONDARY FINDING -Change in subjective parameters