Autoimmune Encephalitis and Other Neuroinflammatory Conditions in an Australian populatio

Not Applicable

Recruiting

• Conditions: euroinflammatory conditions; Neurosarcoidosis; Cerebral vasculitis; Neuromyelitis optica spectrum disorders; Acute demyelinating encephalomyelitis; Autoimmune seizures; new onset refractory status epilepticus; CNS lupus; Susacs; Neuroinflammatory conditions

• Registration Number: ACTRN12621001750875
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-12-21
• Last Update Posted: 27 December 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

* Confirmed or Antibody Positive Autoimmune Encephalitis:

* Possible Autoimmune Encephalitis:
Diagnosis can be made when all three of the following criteria have been met (Grause et al, 2016 criteria):
- Subacute onset (rapid progression of less than 3 months) of working memory deficits (short-term memory loss), altered mental status, or psychiatric symptoms
- At least one of the following:
* New focal CNS findings
* Seizures not explained by a previously known seizure disorder
* CSF pleocytosis (white blood cell count of more than five cells per mm3)
* MRI features suggestive of encephalitis
- Reasonable exclusion of alternative causes

* Other Neuroinflammatory Brain Conditions (ideally prior to steroid commencement)
- Neurosarcoidosis (with CNS involvement in setting of systemic sarcoid, or biopspy proven neurosarcoidosis)
- Cerebral vasculitis (that is biopsy proven)
- Neuromyelitis optica spectrum disorders
(anti aquaporin 4 or anti MOG positive disorders, or meeting the 2016 diagnostic clinical diagnostic criteria of NMO SD) with concomitant encephalitis / decreased conscious state or cognitive deficits
- Acute demyelinating encephalomyelitis
- Autoimmune seizures / possible autoimmune epilepsy / new onset refractory status epilepticus (NORSE)
- CNS lupus (with systemic and hematologic abnormalities diagnostic of lupus) and other neuroinflammatory brain conditions
- Susacs
- Or Other neuroinflammatory conditions - discuss with central coordinator / CPI

* Healthy Volunteer
- Generally well
- not suffering from an autoimmune condition or other neurological condition
- no evidence of infection in the last two weeks
- not currently being treated with steroids

Exclusion Criteria

Infective encephalitis

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterize the various clinical features, EEG, biochemical, haematological and radiological abnormalities associated with autoimmune encephalitis. Outcome to be assessed by review of medical records, serum assays, EEGs, and MRI.[Primary Timepoint (at time of recruitment); secondary timepoint (3 to 6 months after recruitment)];Characterize the central and peripheral immune 'signature' that is associated with autoimmune encephalitis. This will be done by comparing serum assays of patients. [Primary Timepoint (T0 - at time of recruitment); secondary timepoint (3 to 6 months after recruitment)]