The effect of aggressive hydration for prevention of post-ERCP pancreatitis
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0001398
- Lead Sponsor
- Chonnam National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 432
High-risk for post Endoscopic Retrograde Cholangio-Pancreatography (ERCP) pancreatitis ( at least one of the items)
- under 40 years old
- Sphincter Oddi dysfunction
- normal bilirubin blood level
- past history of recurrent pancreatitis
- past history of post Endoscopic Retrograde Cholangio-Pancreatography (ERCP) pancreatitis
- In case of necessity for ductal injection of contrast media
- In case of necessity for sphinceterotomy
- in case of necessity for pre-cut sphincertomy
- in case of necessity for balloon dilatation of sphincter
Exclusion criteria ( at least one of the items)
- Patient without agreement
- <20yrs old or >80yrs old
- severe mental illness
- severe comorbidities ( End-stage renal disease, Advanced Chronic obstructive pulmonary disease, severe heart failure, poorly controlled blood sugar, Etc)
- septicemia (at least two of the following)
-Temperature >38.3 or <36ºc
-Heart rate >90 beats/min
-Tachypnea, respiratory rate > 20 breaths/min
-Leukocytosis (White blood cell > 12,000 microL-1 ) or Leukopenia (White blood cell < 4000 microL-1)
- acute pancreatitis
- chronic pancreatitis
- heart failure ( >NYHA class 2)
- clinical sign of volume overload
- hypernatremia (>150 mEq/L) and/or hyponatremia (<130mEq/L)
- past history of endoscopic sphicterotomy
- past history of balloon dilatation of ampulla of vater
- hypercalcemia and/or metabolic alkalosis
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We analyze the difference of incidence in post ERCP pancreatitis between aggrressive hydration group and standard hydration group. and then analyze the difference depending on fluid types.
- Secondary Outcome Measures
Name Time Method We analyze the difference of incidence in post ERCP hyperamyasemia without pain and/or other complication incidence among the groups