Randomized Clinical Trial Evaluating the Efficacy of Methotrexate in Addition to Anti-H1 Versus Placebo and Anti-H1 in the Treatment of Severe Chronic Idiopathic Urticaria
Overview
- Phase
- Phase 3
- Intervention
- Methotrexate (Novatrex ®) + anti-H1
- Conditions
- Chronic Urticaria
- Sponsor
- University Hospital, Tours
- Enrollment
- 83
- Locations
- 11
- Primary Endpoint
- Number of patients with complete remission of urticaria at 18 weeks
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Chronic urticaria is defined by urticarial lesions persisting at 6 weeks. The cause is not found in about 75% of cases (chronic idiopathic urticaria). The gold standard treatment consists of anti-H1 molecules. In severe cases, refractory to anti-H1, few therapeutic alternatives exist. Methotrexate, which is not expensive and often prescribed by dermatologists, has been efficiently tried in an open study on severe chronic idiopathic urticaria, and also in few case reports.
Detailed Description
Chronic urticaria, defined by its persistence beyond 6 weeks, is a common condition (0.1% to 3% of the general population), occurring at any age. The etiology is not found in nearly 75% of cases (chronic idiopathic urticaria). Chronic idiopathic urticaria may resolve over several months or years. The quality of life of patients is usually strongly spoiled. The gold standard treatment consist of anti-H1 molecules. In severe cases, which are refractory to anti-H1, few therapeutic alternatives exist. Two studies have shown a benefit when adding to anti-H1, montelukast, anti-leukotriene, or cyclosporine. Methotrexate, which is another immunosuppressive drug, cheap and commonly prescribed by dermatologists, has been efficient in severe chronic urticaria, in an open study and in few case reports. Methotrexate, an anti-metabolite drug which inhibits dihydrofolate reductase, is indicated in hematologic malignancies and in autoimmune diseases. It may be given by oral or parenteral administration, once a week, and requires regular monitoring of renal and hepatic function, and blood count.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients who met the diagnostic criteria for chronic idiopathic urticaria, previously treated by
- •3 different molecules of anti-H1 or
- •a combination of 2 different molecules of anti-H1 or
- •1 molecule of anti-H1 with at least a double dose for a total treatment duration of ≥ 3 months before inclusion
- •With persistency of at least 7 days with urticarial lesions in the previous month
Exclusion Criteria
- •Differential diagnosis of chronic idiopathic urticaria (urticarial vasculitis)
- •Treatment with montelukast or immunosuppressive drugs during the previous month
- •Contraindications to methotrexate
- •Allergy to methotrexate
- •Treatment which are contraindicated with methotrexate
- •Pregnancy, possibility of getting pregnant (no effective contraception), breastfeeding
- •Anomalies in liver function (transaminases or liver failure at a rate 1.5 X normal)
- •Severe renal impairment (creatinine clearance calculated by the cockcroft formula \<50 ml / min)
- •Chronic respiratory failure
- •Active infectious chronic diseases (viral hepatitis, HIV)
Arms & Interventions
Group I
The group I will receive the intervention : Methotrexate + anti-H1
Intervention: Methotrexate (Novatrex ®) + anti-H1
Group II
The intervention in group II will include : placebo + anti-H1
Intervention: Placebo + anti-H1
Outcomes
Primary Outcomes
Number of patients with complete remission of urticaria at 18 weeks
Time Frame: at 18 weeks of treatment
Number of patients with complete remission of urticaria at 18 weeks, defined as no urticarial lesion 30 days before W18
Secondary Outcomes
- Efficacy of the treatment in improving symptoms : pruritus(18 weeks and 26 weeks)
- Persistency of the complete remission at 26 weeks(26 weeks)
- Efficacy of the treatment in improving symptoms : duration of lesions(18 weeks and 26 weeks)
- Efficacy of the treatment in improving quality of sleep(18 weeks and 26 weeks)
- Efficacy of the treatment in improving symptoms : outbreaks by week(18 weeks and 26 weeks)
- Efficacy of the treatment in improving quality of life(18 weeks and 26 weeks)
- Efficacy of the treatment in improving facial/cervical urticarial lesions(18 weeks and 26 weeks)
- Tolerance : clinical and biological safety(18 weeks)