A Prospective, Randomized Trial of Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy
试验速览
- 阶段
- 3 期
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- To evaluate the impact of early postoperative enteral feeding
研究概览
简要总结
Pancreaticoduodenectomy is associated with a high incidence of postoperative complications. These postoperative complications could delay postoperative resumption of adequate oral intake. Clinical study on postoperative feeding after pancreaticoduodenectomy is very limited. Method of Nutritional support (Enteral feeding or total parenteral support)after pancreaticoduodenectomy is controversial.
- To evaluate whether early enteral nutrition may be a suitable alternative to total parenteral nutrition
- To evaluate whether enteral feeding improve nutritional status after pancreaticoduodenectomy
详细描述
Pancreaticoduodenectomy is associated with a high incidence of postoperative complications. These postoperative complications could delay postoperative resumption of adequate oral intake. The use of TPN significantly increases postoperative complications, especially those associate with infections. However, method of Nutritional support (Enteral feeding or total parenteral support)after pancreaticoduodenectomy is controversial.
- To evaluate whether early enteral nutrition may be decreased the postoperative complications
- To evaluate whether enteral feeding improve nutritional status after pancreaticoduodenectomy
- To determine the optimal method for postoperative nutritional support
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Periampullar carcinoma
- •Pancreaticoduonectomy
- •KARNOFSKY PERFORMANCE SCALE > 70
- •No history of Major operation
排除标准
- •Creatinine level>3mg/L
- •Ascitis/portal hypertension
- •New York Heart Association class>3
- •Preoperative Radiotheraly/chemotherapy
- •Unresectable primary cancer
- •Palliative surgery
结局指标
主要结局
To evaluate the impact of early postoperative enteral feeding
时间窗: Postoperative 21 days
次要结局
- To evaluate the nutritional status(Postoperative 6 months)