To compare the Effectiveness of Low-Frequency Repetitive Transcranial Magnetic Stimulation (LF-r TMS) vs High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-r TMS)in the Rehabilitation of Parkinsons Disease – an observational study
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Berg Balance Scale(BBS)
研究概览
简要总结
Parkinson’s disease (PD) is defined by a lack of dopamine, and substitution remains primary therapy, but the degeneration of nondopaminergic neurons progresses and leads to the emergence of symptoms refractory to conventional therapy. Among them, difficulties with gait and recurrent falls are common and cause disability in advanced PD.
Transcranial magnetic stimulation (TMS), which, as a non-invasive brain stimulation (NIBS), is used in neurological and psychiatric conditions, especially in Alzheimer’s disease (AD), mild cognitive impairment (MCI), depression, and mental disease
Cortical excitability of the primary motor cortex is altered in patients with Parkinson’s disease (PD). Therefore, modulation of cortical excitability by high-frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex might result in beneficial effects on motor functions in PD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •PD symptomatic for more than 6 months.
排除标准
- •Intracranial metal implant
- •Pacemakers
- •Medication pump implant
- •Cochlear implant
- •History of brain surgery
- •History of seizure or epilepsy
- •Family history of epilepsy
- •Substance abuser
- •History of head trauma.
结局指标
主要结局
Berg Balance Scale(BBS)
时间窗: At baseline and after 2 weeks
次要结局
- Unified Parkinsons Disease Rating Scale (UPDRS)(At baseline, after 2 weeks, 4 weeks and 8 weeks)
研究者
Lt Col Dr Mohit Kataruka
AIIMS Kalyani