EUCTR2007-004529-57-GB进行中（未招募）不适用
Vascular Pleiotrophic Effects of Bisphosphonates in Post Menopausal Women with Osteoporosis: Cellular Mechanisms and Functional Consequences - vascular Effects of Bisphosphonates in osteoporosis
Greenpark Healthcare Trust0 个研究点开始时间: 2007年10月16日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Female
入选标准
- •Inclusion Criteria:
- •Postmenopausal women aged 45 to 60 years of age.
- •T score at or below -2.5 standard deviations of the mean on DEXA scan.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Exclusion Criteria:
- •Women who are pregnant, lactating, not undertaking an acceptable form of contraception, have hypocalcaemia or severe renal impairment (a creatinine clearance less than 30ml/min)
- •Menopause before the age of 40 or surgical menopause.
- •Bone disorders other than osteoporosis.
- •Treatment within six months of study entry with androgen, calcitonin, estrogen, progesterone, fluoride in a tablet form, raloxifene, tamoxifen, lithium or anticonvulsants
- •Previous treatment with bisphosphonates or steroids.
- •Systolic blood pressure of >140 mm Hg or diastolic blood pressure >90 mm Hg at baseline screening examination determined as a mean of 3 readings.
- •History of myocardial infarction, angina, peripheral vascular disease, cerebrovascular disease or diabetes mellitus (fasting blood sugar >7.0mmol/l).
- •History of gastritis or gastro-oesophageal reflux disease.
- •Significant co-morbidity, malignancy or secondary causes of osteoporosis
研究者
相似试验
已完成
不适用
The effects of bisphosphonates on disease activity and bone status in ankylosing spondylitis (BIAS)Ankylosing Spondylitis (AS)Musculoskeletal DiseasesISRCTN87639321Royal National Hospital for Rheumatic Diseases (UK)180
已完成
2 期
Comparison of the effect of Bisphosphonate on the prevention of type 2 diabetes among Osteopenic menopause prediabetes women and Referred to Isfahan Endocrine and Metabolism Research Center.Prediabetes.Impaired glucose tolerance, Menopausal and other perimenopausal disorders, Postmenopausal osteoporosisR73, N95,IRCT2016101530309N1Vice chancellor for research, Isfahan University of Medical Sciences60
已完成
不适用
Effect of treatment with an oral bisphosphonate on markers of bone formation and bone resorption in adults with alkpatonuriaISRCTN12672997niversity Medical Centre Utrecht (UMCU) (The Netherlands)6
尚未招募
不适用
Effect of biphosphonates on teleangiectasia in irradiated breast cancer patientsbiphosphonates and telangiectasia in irradiated breast cancer patients.1000629110047043NL-OMON36371ederlands Kanker Instituut40
进行中（未招募）
1 期
Brittle bones - do they react normally after treatment with bisphosphonates?Osteogenesis ImperfectaMedDRA version: 19.0Level: PTClassification code 10031243Term: Osteogenesis imperfectaSystem Organ Class: 10010331 - Congenital, familial and genetic disordersEUCTR2016-003606-14-GBSheffield Children's NHS Foundation Trust15