The impact of anti-malarial treatment upon the development and persistence of Plasmodium falciparum gametocytes in vitro and in vivo

ondon School of Hygiene and Tropical Medicine (UK)0 个研究点目标入组 600 人开始时间: 2005年7月22日最近更新: 2016年10月17日

适应症

试验速览

暂无简介。

•1. Children one to ten years of age (either sex) attending Farafenni Health Centre, The Gambia, from September to December in each of 2000, 2001 and 2002
•2. Children with a temperature more than 37.5°C, or a history of fever
•3. Blood-film positive for P. falciparum at a density greater than 500 parasites per ml
•4. Signed informed consent was obtained

•1. An inability to take drugs orally
•2. Treatment with antimalarial chemotherapy within the past two weeks
•3. Carriage of circulating gametocytes at presentation
•4. Any evidence of chronic disease or acute infection other than malaria
•5. Domicile outside the study area (approximately 10 km radius)
•6. Any signs or symptoms of severe malaria:
•6.1. Severe anaemia (peripheral blood Packed Cell Volume [PCV] less than 20%)
•6.2. Hyper-parasitaemia (more than 250,000 per ml peripheral blood)
•6.3. Respiratory distress (respiratory rate more than 40 with two of the following: nasal flaring, intercostal indrawing, subcostal recession or grunting)
•6.4. Repeated generalised convulsions (three or more per 24 hours or two witnessed seizures in 24 hours)
•6.5. Haemoglobinuria (dark red/black urine)
•6.6. Jaundice
•6.7. Prostration
•6.8. Circulatory collapse

发起方

ondon School of Hygiene and Tropical Medicine (UK)