Cytokine adsorption in patients with acute on chronic liver failure (CYTOHEP) – a single center, open-label, randomized, controlled intervention trial
- Conditions
- K74.72
- Registration Number
- DRKS00026082
- Lead Sponsor
- niversitätsklinikum Freiburg Department Innere Medizin Klinik für Innere Medizin III
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting stopped after recruiting started
- Sex
- All
- Target Recruitment
- 9
Adult patients (= 18 years) admitted to the University Medical Center Freiburg, Germany
- acute-on-chronic liver failure (ACLF) WITH
a) acute kidney injury according to Kidney Disease: Improving Global Outcome (KDIGO) criteria stage 3 (= 3-fold increase of serum creatinine OR increase of serum creatinine to = 4 mg/dl OR urine output = 0.3 ml/kg/h for = 24 hours OR anuria for = 12 hours) AND
b) serum bilirubin = 5 mg/dl
- known patient will against participation in the study or against the measures applied in the study
- a decision made prior to inclusion to stop further treatment of the patient within the next 24 hours
- no complete remission of malignancy including hepatocellular carcinoma within the past 12 months
- patients on the waiting list for liver transplant or the potential option for being listed for liver transplant within the next 6 months
- liver cirrhosis in patients after liver transplantation
- ongoing intermittent or continuous renal replacement therapy before study inclusion
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum bilirubin reduction after 72 hours
- Secondary Outcome Measures
Name Time Method