Characteristic of coronary vessel by Optical Coherence Tomography in Acute Coronary syndrome

Not Applicable

• Conditions: Health Condition 1: I219- Acute myocardial infarction, unspecified

• Registration Number: CTRI/2020/12/030119
• Lead Sponsor: DrBasant Kumar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Age > 18 years

2. Patients presenting with 1st or recurrent event of acute coronary syndrome ( ACS), unstable angina (USA), non â??ST elevation myocardial infarction ( NSTEMI ), ST elevation myocardial infarction (STEMI)

3. ACS as trigger event - (ESC guidelines) being:

1. Acute cardiac chest pain or angina equivalent consistent with moderate to high-risk unstable angina or myocardial infarction, lasting more than 10 minutes duration during 72 hours before invasive examination AND/OR

2. Evidence for ACS requiring catheterization documented by a) elevated enzymes (CK-MB or hs-Troponin I/T > 99th percentile or in-/decrease) AND/OR

3. ECG with ST-depression >1mm in 2 or more contiguous leads after the J-point AND/OR transient ST-elevation >1mm in 2 or more contiguous leads lasting <30 min OR c) STE-ACS with onset < 24 hours previously and chest pain >30 min ST-elevation >1mm in 2 or more contiguous leads or new left bundle block.

4. Written informed consent

Exclusion Criteria

EXCLUSION CRITERIA

1. Known systolic heart failure with left-ventricular ejection fraction (LV-EF<= 30 %).

2. Cardiogenic shock or heart failure requiring intubation, inotropes; diuretics or mechanical circulation support.

3. Refractory ventricular arrhythmia requiring pharmacologic or defibrillator therapy.

4. Renal insufficiency with serum-creatinine >= 1.5 mg/dl.

5. ACS with culprit lesion in a bypass graft.

6. No suitable anatomy of culprit lesion for OCT:

o severe calcification or extreme tortuosity of culprit lesion.

o culprit lesion with very distal location.

o infarct vessels with an diameter > 4 mm or < 2 mm.

7. TIMI flow <= 2

Study & Design

• Study Type: Observational
• Study Design: Not specified