Improvements in Aerobic Performance Following a Four-week Period of High Intensity Interval Training in the Elderly.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Mean anaerobic threshold improvement following 4 week HIT protocol.
研究概览
简要总结
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old). Participants will undergo a wide range of physical fitness measures followed by a four week exercise protocol. Determination of improvement will be by repeated testing of the physical measures taken for baseline. The primary outcome measure will be anaerobic threshold. There will also be a subgroup of participants who will undergo muscle biopsy and D2O ingestion to allow an insight into the mechanistic basis behind exercise training response in this age group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged over 70 years.
- •Sufficient mobility to be able to exercise on a static exercise bike.
- •Availability for the entire trial period.
- •Sufficient capacity to consent for the trial.
排除标准
- •Participants under the age of 70 years.
- •Participants with a significant past medical history of:
- •Myocardial infarction (within last 6 months)
- •Unstable Angina
- •Heart failure (NYHA class III/IV)
- •Uncontrolled Hypertension (BP>160/100)
- •Previous stroke/TIA
- •Severe respiratory disease inc. known pulmonary hypertension(>25 mmHg), Forced -Expiratory Volume in 1 second <1.5l.
- •Brittle asthma / exercise induced asthma
- •Known cerebral aneurysm or abdominal aortic aneurysm.
- •Cognitive impairment, which may reduce individuals' ability to provide informed consent.
- •Inclusion in a recent study which included any form of exercise, taking a drug or ionising radiation.
- •Exclusion criteria pertaining specifically to muscle biopsies:
- •Current use of anticoagulation (i.e. Warfarin/Clopidogrel/Rivaroxaban)
- •Any pre-existing clotting disorders known to the patient (i.e. haemophilia).
- •Family history of severe bleeding requiring medical intervention.
- •Any musculoskeletal deformity or skin conditions making the taking of a biopsy unsuitable as deemed by the medical practitioner taking that sample.
- •Lack of capacity to fully consent for the procedure.
研究组 & 干预措施
High intensity exercise training
HIT training protocol.
干预措施: HIIT Device: ergometer (Behavioral)
结局指标
主要结局
Mean anaerobic threshold improvement following 4 week HIT protocol.
时间窗: 4 weeks
Measured via cardiopulmonary exercise testing (mls/kg/min and absolute value L/kg). Pre-Post testing.
次要结局
- Body composition(4 weeks)
- Muscle architecture(4 weeks)
- Feasibility(4 Weeks)
- Mean VO2 peak improvement following 4 week HIT protocol.(4 weeks)
- Muscle protein synthesis(4 weeks)
- Quality of life improvement(4 weeks)
- Daily Activity Level(4 weeks)
- Physical Activity Score(4 weeks)