Interaction of Muscle Dystrophy, Glucose Metabolism and Insulin Sensitivity
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- muscle dialysate lactate
研究概览
简要总结
The aim of this project to characterize systemic and organ-specific (subcutaneous adipose tissue and skeletal muscle) metabolic responses at rest and during standardized, moderate exercise after an oral glucose load in patients with various geneticaly heritable foms of skeletal muscle dystrophies. Metabolic responses will be monitored by indirect calorimetry (canopy and/or metabolic chamber at rest and during exercise) and microdialysis (adipose tissue and skeletal muscle at rest) before and after an oral glucose load (75 g).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •controls: healthy, no metabolic, endocrine, neurologic or other diseases
- •patients: genetically confirmed diagnosis of muscle dystrophy
排除标准
- •known hemorrhagic diseases / coagulopathies
- •intake of oral anti-coagulant drugs (control of PTT, INR and platelet count before study entry)
- •insulin-dependent Diabetes mellitus
- •pregnancy and lactation period
- •chronic use of non-steroidal antiphlogistics
- •alcohol and drug abuse
- •Claustrophobia • gleichzeitige Teilnahme an einer anderen Studie; Teilnahme an einer Studie vor weniger als zwei Monaten Unfähigkeit, die mündlichen und schriftlichen Informationen zur Studie zu verstehen und das schriftliche Einverständnis zu geben
结局指标
主要结局
muscle dialysate lactate
时间窗: 15 minutes intervals after glucose over three hours
marker for anaerobic glycolysis
muscle dialysate pyruvate
时间窗: 15 minutes intervals after glucose over three hours
marker for aerobic glycolysis
次要结局
- muscle tissue perfusion(15 minutes intervals after glucose over three hours)
- energy expenditure(15 minutes intervals after glucose over three hours)
研究者
Michael Boschmann
Dr. med.
Charite University, Berlin, Germany