Altered interferon-gamma response in patients with Q-fever fatigue syndrome

• Conditions: Q-fever; 10002252; Q-fever fatigue syndrome

• Registration Number: NL-OMON42843
• Lead Sponsor: Algemene Interne Geneeskunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 104

Inclusion Criteria

• Diagnosis of QFS according to national LCI-guideline Q fever fatigue syndrome (QFS);
• Score >=40 on the subscale fatigue of the Checklist Individual Strength (CIS) at time of diagnosis
• Severe functional impairment on Sickness Impact Profile-8 (SIP-8), defined as a SIP total score >=700 at time of diagnosis;
• Age >=18.

Exclusion Criteria

• Use of immunosuppressant drugs in the past 3 months ;
• Pregnancy;
• Use of doxycycline in the past 6 months.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• Cytokine concentrations (IL-2 and IFN&gamma;)<br /><br>• CIS score, subscale on fatigue</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Chemokine levels of CXCL 8/9/10/11<br /><br>- Q-fever serology , using Immunofluorescence Assay (IFA)</p><br>