Effect of Fire-Needle Combined With Regular Acupuncture on Pregnancy Outcome in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- β-hCG-positive pregnancy
研究概览
简要总结
This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture.
A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture).
Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •(1)18 ≤age ≤40 years; (2) ≥2 previous failures of high-quality embryo transfer without clinical pregnancy
排除标准
- •(1) preimplantation genetic testing cycles; (2) use of donor oocytes; (3) missing key data on treatment or outcome
研究组 & 干预措施
non-acupuncture group
干预措施: no acupuncture (Other)
regular acupuncture group
干预措施: regular acupuncture (Device)
fire needle combination group
干预措施: Fire needle combination group (Device)
结局指标
主要结局
β-hCG-positive pregnancy
时间窗: 1 year
Test for hCG in the blood day 14 post-transfer
Clinical pregnancy
时间窗: 1 year
ultrasonographic detection of an intrauterine gestational sac following embryo transfer
Miscarriage
时间窗: 1 year
defined as spontaneous pregnancy loss occurring after ultrasound-confirmed clinical pregnancy
次要结局
未报告次要终点
研究者
Cui Hong Zheng
Principal Investigator, Clinical Professor
Huazhong University of Science and Technology