Prospective Epidemiological Study of the Prevalence of HLA-B*5701 in HIV-1 Infected UK Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,502
- 试验地点
- 1
- 主要终点
- Prevalence of HLA-B*5701 in the UK population via central labs
研究概览
简要总结
This is a study to determine the prevalence of a genetic marker, HLA-B5701, in the UK population. HLA-B*5701 has been strongly associated with the risk of an allergic reaction to a HIV medicine, Abacavir. The allergic reaction is known as a hypersensitivity reaction.
The study is a prospective study inviting HIV-1 positive patients over the age of 18 years to participate. Each participant will complete one study visit. They will be asked for details of their background including their age, sex, ethnicity, country of origin and parental country of origin.
They will be asked to give two samples to test for the presence of the genetic marker HLA-B*5701. The two samples are:
- A cheek swab
- A blood sample
In selected centres patients may be asked to provide up to two additional blood samples. These samples will be used to help develop and validate new methods of determining HLA-B*5701 testing.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Prevalence of HLA-B*5701 in the UK population via central labs
时间窗: 2 Hours
The widespread of HLA-B\*5701 applied in the selected area in each participant of the UK population was tested via central labs. The result is summarized here.
次要结局
- Prevalence of HLA-B*5701 in major UK ethnotypes in the study population.(2 Hours)
- Description of HLA-B*5701 in the UK population via local labs.(2 Hours)