Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation
- Conditions
- VNS Implanted Tinnitus Patients
- Interventions
- Device: Vagus Nerve Stimulation
- Registration Number
- NCT03143842
- Lead Sponsor
- The University of Texas at Dallas
- Brief Summary
The purpose of this study is to investigate whether it is possible to accelerate learning and improve memory performance in VNS implanted tinnitus participants by pairing VNS with a verbal paired-associate learning task.
- Detailed Description
Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.
Vagus Nerve Stimulation (VNS) has been delivered to patient populations (e.g. depression, epilepsy, ...) for more than 25 years and there has been some indications that this technique has effects on cognition, more specifically memory. Studies have investigated VNS as a way to improve memory performance and it has been shown in some studies to enhance memory in rats and humans. It has also demonstrated to produce changes in the electrophysiological and metabolic profile of forebrain and brainstem structures involved in learning and memory.
To investigate whether VNS can accelerate learning and improve associative memory when learning word pairs, we will investigate the performance of VNS implanted participants on a Verbal Paired-Associate memory task and compare their performance on the words that were learned while paired with VNS in contrast to their performance on the words that were learned while unpaired with VNS and in contrast to their performance on the words that were learned without VNS (i.e. 3 types/groups of words: paired with VNS, unpaired with VNS and without VNS) during the first visit and 1 day,1 week and 1 month after their first visit.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- 18-70 years old
- Native English speaker
- Acquainted with the foreign language used in the learning task
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Vagus Nerve Stimulation Vagus Nerve Stimulation VNS paired with word pairs, VNS unpaired with word pairs, no VNS
- Primary Outcome Measures
Name Time Method Associative Memory assessed by a Verbal Paired-Associate test Baseline session and 1 day, 1 week and 1 month after the baseline session Changes in performance in the Verbal Paired-Associate memory task is compared between three groups of learned word pairs (1) learned word pairs paired with VNS, (2) learned word pairs unpaired with VNS, (3) learned word pairs paired without VNS
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The University of Texas of Dallas
🇺🇸Richardson, Texas, United States