Acute and Long-Term Outcome Investigations of Fenofibrate on Severely Burned Patients

Phase 4

Terminated

• Conditions: Second or Third Degree Burns
• Interventions: Drug: Sugar Pill; Drug: Fenofibrate

• Registration Number: NCT01574131
• Lead Sponsor: The University of Texas Medical Branch, Galveston

Brief Summary

The purpose of this study is to learn the following: whether long-term treatment (6 months) with fenofibrate will decrease burn related sugar and fat increased in the blood and help prevent muscle loss and improve wound healing.

Detailed Description

Following severe burn injury in human patients the mitochondrial fat oxygenation capacity is decreased in muscle. This is associated with a corresponding progression in the severity of the resistance to the action of insulin on glucose disposal and protein synthesis and breakdown in muscle, regenerating wound and liver.

Fatty acids or their active intracellular products ( e.g. Diacylglycerol, acyl- Coenzyme A(CoA) or acylcarnitine) are the direct inhibitors of insulin action, rather than tissue triglycerides(TG) itself. In other words, impaired mitochondrial fatty acid oxygenation is the mechanism that causes altered lipid metabolism that ultimately contributes to insulin resistance.

Accumulation of active fatty acid products, such as Diacylglycerol, acyl-CoA or acylcarnitine esters in muscle cells is due to the rate of uptake of plasma free fatty acids(FFA) exceeding the rate of oxygenation within muscle due principally to a reduced capacity of mitochondria to oxidize fatty acids.

Decreasing insulin sensitivity in muscle is related to impaired insulin signaling. This will be reflected by increased activity of protein kinase C (PKC). Because PKC is thought to exert its regulatory effect primarily on either tyrosine kinase activity on the insulin receptor or downstream kinase insulin receptor substrate (IRS) phosphorylation, these elements of the insulin signaling cascade will be decreased. In turn, elements of insulin signaling related to the response of muscle glucose (PI3 Kinase) and protein (P70S6k)metabolism will be reduced. The investigators propose that increased tissue PKC activity will be associated with increased tissue concentration of Diacylglycerol, acyl-CoA or acylcarnitine. The investigators hypothesize that the treatment of patients with the peroxisome proliferator-activated receptor (PPAR) alpha antagonist fenofibrate will improve mitochondrial capacity to oxidize fatty acids. Insulin sensitivity in muscle, skin and liver in terms of both glucose and protein metabolism will be improved by fenofibrate treatment.

Study Timeline

• Study First Submitted: 2012-03-22
• Study First Submitted QC: 2012-04-09
• Study First Posted: 2012-04-10
• Study Start: 2012-05
• Status Verified: 2016-02
• Primary Completion: 2016-02
• Study Completion: 2016-02
• Last Update Submitted: 2019-11-26
• Last Update Posted: 2019-11-29

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• ≥40% Burn
• ages 4-20years
• body weight ≥10kg

Exclusion Criteria

• <40% burn
• ages <4->20 years
• body weight <10kg
• Respiratory insufficiency
• Multiple fractures
• History of cancer in last 5 years
• Bilirubin>3mg/dL
• Serum Creatinine>3mg/dL after fluid resuscitation
• Glutamyl-Oxaloacetic Transaminase(GOT) >40 Units/L
• Glutamyl-Pyruvate Transminase(GPT) >51 Units/L
• Associated head injuries requiring therapy
• Associated injuries to the chest or abdomen requiring surgery
• Receipt of any experimental drug other than the ones supplied within two months of study
• Any metal in body including rods, cardiac defibrillators, pacemaker, etc
• Orthopedic casting which would prevent placement in MRI
• Hepatitis
• Abnormal EKG
• Electrical burns

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sugar pill	Sugar Pill	pill
Fenofibrate	Fenofibrate	ppar-alpha agonist

Primary Outcome Measures

Name	Time	Method
Mitochondrial fatty acid oxygenation	6 months post injury	Changes in mitochondrial oxygen consumption, Palmitoyl-CoA, palmitoyl-L-Carnitine, Pyruvate, Malate, Malonyl-CoA

Secondary Outcome Measures

Name	Time	Method
Protein Metabolism	6 months post injury
Glucose Metabolism	6 months post injury
Amino Acid Metabolism	6 months post injury
Insulin sensitivity	6month post injury	Muscle amino acid uptake, protein synthesis and breakdown. Insulin receptor tyrosine kinase activity, insulin receptor substrate activity,protein kinase C activity,glucose uptake and enrichment. Fractioned synthetic rate of plasma proteins

Trial Locations

Locations (1)

University of Texas Medical Branch; 🇺🇸 Galveston, Texas, United States