ACTRN12612000501842招募中未知
A randomised controlled trial of the effects of progressive resistance training, high protein/low glycaemic index diet and gait re-training on knee adductor moment in overweight/obese adults with medial knee osteoarthritis.
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 125
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 40 Years 至 o limit（—）
- 性别
- All
入选标准
- •The following inclusion criteria enable the volunteer to participate in the THE LO Study:
- •- Primary osteoarthritis of at least one knee
- •- BMI >27.5 kg/m2
- •- Aged 40 years or more
- •Criteria used to make OA diagnosis:
- •- Knee pain
- •- +ve at least 1 of 3:
- •- Age > 50 years
- •- Stiffness < 30 minutes
- •- Crepitus
- •- +ve Osteophytes
- •- +ve Xray diagnosis (or other previous scans)
排除标准
- •The following conditions permanently exclude the subject from participation in the THE LO STUDY:
- •- Unstable aortic aneurysm
- •- Rapidly progressive or terminal illness
- •- Severe left ventricular dysfunction/end stage congestive heart failure
- •- Severe aortic stenosis
- •- Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemachromatosis, Wilson's disease and other rare forms of arthritis)
- •- Previous or anticipated (within 6-12 months) joint replacement operation
- •- Severe psychosis or behavioural disturbance or cognitive impairment
- •- Surgery to any structure (cartilage, bone, tendons, ligaments, muscle) in or around the knee joint
- •The following conditions require medical intervention or re-evaluation prior to participation in THE LO Study:
- •- Abnormal resting ECG
- •- Angina (unstable)
- •- Arrhythmias or heart block (uncontrolled)
- •- Breathing problem or motion disorder
- •- Cardiac surgery (within last 6 months)
- •- Cataract extraction (within last month)
- •- CHF (uncontrolled)
- •- Cognitive impairment (mild-moderate)
- •- COPD / CAL (uncontrolled)
- •- Diabetes (uncontrolled, eg. HbA1c > 10%)
- •- Deep venous thrombosis (acute)
- •- Endocarditis
- •- Fracture (recent or delayed union)
- •- Haemorrhoids (severe)
- •- Hernia (unrepaired or symptomatic; abdominal or inguinal)
- •- Hypertension (uncontrolled; arterial or pulmonary)
- •- Knee joint injury within the past 6 months
- •- Knee Injections (e.g. Corticosteroids – cortisone); no more than 2 in the last 5 years, and only one in the last 6 months.
- •- Myocardial infarction (acute; within last 6 months)
- •- Neurological disease (rapidly progressive or unstable)
- •- Pericarditis (acute)
- •- Pulmonary embolism or infarction (acute)
- •- Retinopathy, recently treated, unstable
- •- Severe functional limitation (unable to walk unaided by a person)
研究者
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