A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Systolic Blood Pressure (mmHg)
研究概览
简要总结
The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5. As the general population ages, the spinal cord injury (SCI) population is also aging and it is estimated that 14% is older than 60. Although persons with SCI are living longer, life expectancy remains below that of the general population with cardiovascular and cerebrovascular diseases accounting for more than 25% of all deaths since 1995. Similar to findings in the general population, BP dysregulation may impact cognitive function, and investigators reported poorer performance on tasks of memory and attention processing in hypotensive individuals with SCI compared to a normotensive SCI cohort. Thus, it is imperative that investigators work to minimize the impact of cognitive deficits on these aspects of life quality in persons with SCI as they age. Therefore the goals of this study are: Study 1) to compare cardiovascular, cerebrovascular and cognitive function and fMRI between older individuals with SCI (50-75 years) and older age-matched controls and Study 2) to determine 3-5 year longitudinal changes in cardiovascular, cerebrovascular and cognitive function and fMRI in relatively young individuals with SCI (28-54 years) compared to relatively young age-matched controls.
详细描述
All potential subjects will undergo a two-part screening process which consists of an initial screening via telephone and a detailed, in-person screening. Eligible subjects will be invited to participate in a 4 hour laboratory visit during which their arterial stiffness, blood pressure, heart rate, respiration rate and, blood flow to the brain will be monitored at rest and during a comprehensive series of cognitive tests. For Study 1 (cross-sectional), 40 older (50-75 years) individuals with SCI and 20 age-matched non-SCI controls will be recruited. For study 2 (longitudinal), 30 individuals (28-54 years) with SCI and 20 age-matched non-SCI will be recruited from previous enrollment in the Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in SCI study to learn the longitudinal changes in cardiovascular, cerebrovascular and cognitive health.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 28 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Study 1) Between the ages of 50-75 years old
- •Study 2) Between the ages of 28-54 years old
- •Completed Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health study
- •For Both:
- •Primary language is English
- •Additional Inclusion Criteria: SCI Subjects
- •Level of injury between C1-T12;
- •Non-ambulatory (wheelchair dependent);
- •AIS grade A, B, or C;
- •Injury occurred more than 1 year ago.
排除标准
- •Acute illness or infection;
- •Controlled or uncontrolled hypertension or Diabetes mellitus;
- •Documented history of traumatic brain injury;
- •Epilepsy or seizure disorders;
- •Multiple sclerosis & Parkinson's disease;
- •Psychiatric disorders (post-traumatic stress disorder, schizophrenia, bipolar disorder);
- •Alzheimer's disease & dementia
结局指标
主要结局
Systolic Blood Pressure (mmHg)
时间窗: Up to 3 years
To determine change in systolic blood pressure from seated rest to seated cognitive testing in subjects with and without spinal cord injury.
次要结局
- Cerebral Blood Flow Velocity (cm/second) from the middle cerebral arteries(Up to 3 years)
- Performance on tests of memory (PASAT) and processing speed (SDMT).(Up to 3 years)
研究者
Jill M. Wecht, Ed.D.
Research Health Scientist
James J. Peters Veterans Affairs Medical Center