NL-OMON26725已完成不适用
Duloxetine for chronic osteoarthritis pain; an important alternative?
Erasmus MCZonMw0 个研究点目标入组 362 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 362
研究概览
简要总结
van den Driest JJ, Schiphof D, Luijsterburg PAJ, et al. Effectiveness and costeffectiveness of duloxetine added to usual care for patients with chronic pain due to hip or knee osteoarthritis: protocol of a pragmatic openlabel cluster randomised trial (the DUO trial). BMJ Open 2017;7:e018661. doi:10.1136/ bmjopen-2017-018661 van den Driest JJ, Schiphof D, Koffeman AR et al. No added value of duloxetine in patients with chronic pain due to hip or knee osteoarthritis: a cluster-randomized trial. Arthritis Rehumatol 2022; Jan 6. doi: 10.1002/art.42040
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1) having hip or knee OA based on the clinical ACR criteria, and 2) having chronic pain (most days of the last three months) in hip or knee, and 3) either: (i) a contra-indication for NSAIDs; (ii) adverse reactions of NSAIDs; or (iii) insufficient benefit of NSAIDs.
排除标准
- •1) on waiting list for hip/knee replacement, and 2) use of antidepressants, 3) contra-indication of duloxetine (use of Monoamine Oxidase Inhibitors, having uncontrolled narrow-angle glaucoma, in combination with (other) central nervous system acting drugs, in combination with thioridazine, hypersensitivity to duloxetine)
研究者
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