The role of Growth differentiation factor 11 in the pathogenesis of chronic obstructive pulmonary disease
Not Applicable
Recruiting
- Conditions
- chronic obstructive pulmonary disease (COPD)
- Registration Number
- JPRN-UMIN000019067
- Lead Sponsor
- Department of Respiratory Medicine, TohokuUniversityGraduateSchoolof Medicine
- Brief Summary
The levels of GDF11 are decreased in both the plasma and lungs of COPD patients, and inversely correlate with the severity of the airflow limitation; treatment with GDF11 inhibits the cigarette smoke (CSE)-induced cellular senescence and production of inflammatory mediators in vitro.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
Not provided
Exclusion Criteria
patients and healthy volunteers who deny participating in this study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate the expression of GDF11 in COPD patients is decreased and whether GDF11 suppress the cellular senescence of human lung fibroblasts
- Secondary Outcome Measures
Name Time Method