Carotid Atherosclerosis in Patients With Aortic Coarctation

Completed

• Conditions: Atherosclerosis; Aortic Coarctation
• Interventions: Other: Ultrasound measurement

• Registration Number: NCT03999073
• Lead Sponsor: Skane University Hospital

Brief Summary

Despite aortic coarctation (CoA) repair these patients have cardiovascular complications and coronary artery disease is the most common cause of death.

Detailed Description

The aim with this study was to measure intima-media thickness (IMT) and plaques in arteries compared to cardiovascular markers in controls and patients with CoA.

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2019-01-01
• Study Completion: 2019-01
• Status Verified: 2019-06
• Study First Submitted: 2019-06-21
• Study First Submitted QC: 2019-06-24
• Last Update Submitted: 2019-06-24
• Study First Posted: 2019-06-26
• Last Update Posted: 2019-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

• sex and age-matched controls

Exclusion Criteria

• acute and chronic inflammation disease, underlying malignancies and diabetes mellitus.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Subjects with coarctation	Ultrasound measurement	-
Controls	Ultrasound measurement	-

Primary Outcome Measures

Name	Time	Method
Intima-media thickness	Intima-media thickness will be measured at one time point namely at inclusion. Data will be reported when study is completed, an average of 2 year.	Measurement in mm

Secondary Outcome Measures

Name	Time	Method
Cardiovascular markers	Blood samples will be taken at one time point namely at inclusion. Then biomarkers will be analysed when study is completed. Data will be reported when study is completed, an average of 2 year.	A multiplex platform to analyze circulating blood levels biomarkers was used.