Preconditioning of One-lung Ventilation for Lung Protection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 136
- 试验地点
- 2
- 主要终点
- P/F ratio
研究概览
简要总结
To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.
详细描述
For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia.
Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation.
Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position
排除标准
- •Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease
- •Thoracic surgery for pneumonectomy
研究组 & 干预措施
One-lung ventilation
Before surgical incision, 2-min of OLV followed by 2-min of TLV (1 cycle) is performed for 5 cycles.
干预措施: One-lung ventilation (Other)
Two-lung ventilation
Maintain two-lung ventilation until surgical incision
结局指标
主要结局
P/F ratio
时间窗: 30min after surgical incision
PaO2/FIO2 ratio
Incidence of hypoxemia
时间窗: during one-lung ventilation, up to 5 hours
SpO2 \< 95%
次要结局
- Pulmonary complications(6, 24, 48 hours after surgery, during hospital stay.)
研究者
Jeong-Hwa Seo
Professor
Seoul National University Hospital