Preconditioning of One-lung Ventilation for Lung Protection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- One Lung Ventilation
- Sponsor
- Seoul National University Hospital
- Enrollment
- 136
- Locations
- 1
- Primary Endpoint
- P/F ratio
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.
Detailed Description
For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia. Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation. Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery
Investigators
Jeong-Hwa Seo
Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position
Exclusion Criteria
- •Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease
- •Thoracic surgery for pneumonectomy
Outcomes
Primary Outcomes
P/F ratio
Time Frame: 30min after surgical incision
PaO2/FIO2 ratio
Incidence of hypoxemia
Time Frame: during one-lung ventilation, up to 5 hours
SpO2 \< 95%
Secondary Outcomes
- Pulmonary complications(6, 24, 48 hours after surgery, during hospital stay.)