Preconditioning of One-lung Ventilation
Not Applicable
Completed
- Conditions
- One Lung Ventilation
- Interventions
- Other: One-lung ventilation
- Registration Number
- NCT03282032
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.
- Detailed Description
For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia.
Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation.
Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 136
Inclusion Criteria
- Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position
Exclusion Criteria
- Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease
- Thoracic surgery for pneumonectomy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description One-lung ventilation One-lung ventilation Before surgical incision, 2-min of OLV followed by 2-min of TLV (1 cycle) is performed for 5 cycles.
- Primary Outcome Measures
Name Time Method P/F ratio 30min after surgical incision PaO2/FIO2 ratio
Incidence of hypoxemia during one-lung ventilation, up to 5 hours SpO2 \< 95%
- Secondary Outcome Measures
Name Time Method Pulmonary complications 6, 24, 48 hours after surgery, during hospital stay. Acute lung injury, acute respiratory distress syndrome, atelectasis, pneumonia
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of