Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Evolutive profile of the inflammatory response during septic shock
研究概览
简要总结
Septic shock is a frequent pathology responsible for over 30000 deaths/year in France. Its outcome has not been improved despite the knowledge on inflammatory processes; a reason for these lack of results may lay on the lack of data on the precise dynamics of inflammatory and anti-inflammatory cascades and their consequences. We intend to achieve accurate monitoring of the inflammatory process on a small group of non-immunocompromised patients. Our goal is to obtain quality data, repeated over time, by limiting the technical variability.
详细描述
The aim is to obtain precise data on the dynamics of cytokines, oxydative stress and hormonal response on immunocompetent adults during septic shock.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient over 18 years admitted in ICU.
- •Clinical evidence of infection, suspected or proved, during the 48hrs following the hospital entry.
- •Systemic inflammatory response syndrome.
- •Shock defined as arterial hypotension (<90mmHg)not responding to adequated filling.
排除标准
- •Patient under guardianship or trusteeship
- •Pregnant or lactating women
- •Not affiliated to the social security
- •Deprived of liberty by court decision
- •Patients hospitalised without their approval
- •Shock related to another cause than infection
- •Long term corticothérapy
- •On-going chemiothérapy, AIDS
- •Bedridden patient
结局指标
主要结局
Evolutive profile of the inflammatory response during septic shock
时间窗: Hospitalisation in ICU
次要结局
- Research for early prognosis factors(Hospitalisation in ICU)
研究者
AdministrateurDRC
Pr JF TIMSIT
University Hospital, Grenoble