TCTR20210807005已完成2 期
Probiotic, Lactobacillus rhamnosus GG, in Reducing Gut-derived Uremic Toxins in Non-dialysis Chronic Kidney Disease Patients, A Randomized Controlled Trial
Ratchadapiseksompotch Research Fund0 个研究点目标入组 60 人开始时间: 2021年8月7日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
actobacillus rhamnosus GG changed the structure of gut microbiome phyla, therefore improved gut dysbiosis, attenuated GDUT production, and reduced inflammatory responses. Probiotics could play a beneficial role in retarding CKD progression in the future.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •Age > 18 years old
- •Diagnosed CKD stage 3-5 or estimated glomerular filtration rate (eGFR)
- •between 10-60 ml/min/mm2 who did not undergo renal replacement therapy
排除标准
- •Estimated glomerular filtration rate (eGFR ) less than 10 ml/min/mm2
- •History of kidney transplant
- •On immunosuppressive therapy
- •History of Renal replace therapy except RRT from acute kidney failure
- •Pregnancy at date of participation
- •Diagnosed Inflammatory bowel disease or infection at bowel
- •Diagnosed Cancer who has to ongoing Chemotherapy or in stage 4
- •End-stage diseases : Congestive heart failure NYHA 4, End-stage lung diseases, Cirrhosis
- •Child-Pugh B,C, or patient who has Karnofsky performance score less than 40
研究者
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