Metabolomic Response to Meal Ingestion
- Conditions
- Healthy
- Interventions
- Dietary Supplement: Normal meal
- Registration Number
- NCT03383250
- Brief Summary
The investigators have recently shown that postprandial sensations correlate with changes in circulating metabolites after a meal ingestion; however this phenomenon was demonstrated with a meal load up to the level of tolerance which involved an unpleasant fullness sensation. The aim of the present study is to determine changes in circulating metabolites of a satiating pleasurable meal. Healthy men (n = 32) will be evaluated after a 5 h fast. Perception measurements and blood samples will be taken before and 20 minutes after ingestion of a palatable probe meal (juice and warm ham and cheese sandwich, total 300 ml, 440 kcal). NMR spectroscopy will be performed to determine plasmatic Low Molecular Weight Metabolites (LMWM) and to characterize lipoprotein profiles (number of particles, lipid content and size of the main three lipoprotein classes (VLDL, LDL and HDL). Homeostatic (satiety, fullness) and hedonic sensations (digestive well-being, mood) will be measured by 10 cm analogical scales.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 32
- non obese
- history of gastrointestinal symptoms
- prior obesity
- use of medications
- history of anosmia and ageusia
- current dieting
- alcohol abuse
- psychological disorders
- eating disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Meal ingestion Normal meal -
- Primary Outcome Measures
Name Time Method Metabolomic response in serum 30 min
- Secondary Outcome Measures
Name Time Method Change in abdominal discomfort/pain sensation measured after the test meal 1 day Change in average abdominal discomfort/pain measured by 10 score scales at the end of the test meal
Change in mood measured after the test meal 1 day Change in average mood measured by 10 score scales at the end of the test meal.
Change in satiety measured after the test meal 1 day Change in average satiety measured by 10 score scales at the end of the test meal
Change in digestive well-being measured after the test meal 1 day Change in average well-being measured by 10 score scales at the end of the test meal.
Change in fullness sensation measured after the test meal 1 day Change in average fullness measured by 10 score scales at the end of the test meal