Bone health in professional cycling

Recruiting

Conditions: botgezondheid
Bone health
osteoporosis

Registration Number: NL-OMON52815

Lead Sponsor: Hogeschool van Arnhem en Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 75

Inclusion Criteria

Male and female (18y+)
Professional cyclist competing in UCI*s WorldTour competition or a talent of
that team.
Former professional cyclists (35y+)
Willing to give written informed consent.
Willing to comply with study procedures.

Exclusion Criteria

Having a history of medical events or medication use that may significantly
affect bone metabolism, to be decided by the principal investigator.
Medication use that may affect tests within this study must be minimal 3 months
before Day 01 of this study.
Participation in any clinical trial including blood sampling and/or
administration of substances up to 30 days before Day 01 of this study
A recent injury that may significantly affect BMD, to be decided by the
principal investigator.
Participants who have had a traumatic fracture recently (<2 years) at either
distal radii and tibiae will be excluded from the HR-pQCT measurement.
Female participants who are pregnant

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Bone health: whole body and regional (lumbar spine and femoral hip) bone<br /><br>mineral density and bone mineral content as determined by dual-energy X-ray<br /><br>absorptiometry (DXA).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Cycling exercise volume during the preceding 12 months (for retired cyclists we<br /><br>obtain the average volume during a 5 year period in their career).<br /><br>Dietary intake (energy, macronutrients, calcium, vitamin D)<br /><br>Blood parameters of bone health: Procollagen type I N propeptide (PINP),<br /><br>carboxy-terminal crosslinking telopeptide of type I collagen (CTX-I),<br /><br>calcitonine, parathyroid hormone (PTH), testosterone oestrogen.<br /><br>History of sports participation during life.<br /><br>Bone microarchitecture and bone strength will be assessed by HR-pQCT. A scan<br /><br>takes ~2 minutes, is painless, non-invasive and involves only low radiation<br /><br>exposure (effective radiation dose of ~5 µSv).</p><br>