A Phase 1/2 Open-Label Study to Assess the Safety, Tolerability, and Pharmacokinetics of Intravenous Infusion of MB07133 in Subjects With Unresectable Hepatocellular Carcinoma and Child-Pugh Class A Liver Function

Ligand Pharmaceuticals4 个研究点分布在 3 个国家目标入组 28 人开始时间: 2003年9月最近更新: 2011年8月12日

适应症

干预措施

试验速览

阶段: 1 期
状态: 已完成
发起方: Ligand Pharmaceuticals
入组人数: 28
试验地点: 4
主要终点: Safety and tolerability

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. MB07133 is being developed for the treatment of inoperable HCC, using a platform technology known as HepDirectTM, which enables drugs to be targeted specifically to the liver. The objective for this study is to determine the safety and tolerability of MB07133.

详细描述

To determine the maximum tolerated dose of MB07133 when administered as a 7-day continuous i.v. To characterize the safety profile and the pharmacokinetics of MB07133 and metabolites during and after continuous infusion. To determine the effect of MB07133 on hepatocellular carcinoma (HCC) tumor size.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Patients with a diagnosis of local unresectable HCC confirmed by histology using fine needle aspirate (FNA) or liver biopsy. "Local" is defined as disease either restricted to the liver or contiguous with the liver and no identifiable extrahepatic disease.
•Patients with Child-Pugh Class A liver function. For purposes of this trial, an eligible patient must not have Encephalopathy or Ascites and the total Child-Pugh score cannot be greater than 6 at baseline
•Males or females 18 years of age or older
•Ability to provide written informed consent before initiation of any study-related procedures and ability, in the opinion of the Principal Investigator, to comply with all the requirements of the study
•Male and female subjects who are surgically sterile, who remain abstinent, or who agree to practice double barrier forms of birth control from screening through 30 days (females) and 90 days (males), from the last dose of study medication

排除标准

•History of or presence of clinically significant acute or unstable cardiovascular, cerebrovascular (stroke), renal, GI, pulmonary, immunological (with the exception of the presence of hepatitis B virus [HBV], HCV hepatitis, or cirrhosis), endocrine, or central nervous system disorders
•Patient has a history of cancer other than hepatocellular (excluding resected basal cell carcinoma; or curatively resected stage 1 or less cervical cancer if disease free for 5 years or more).
•Patients with distant metastasis or extrahepatic disease
•An Eastern Cooperative Oncology Group (ECOG) performance status score of greater than or equal to 2
•Current encephalopathy or current treatment for encephalopathy
•History of drug or alcohol abuse within 6 months before screening
•History of, or current clinically significant mental disorder or an antagonistic personality that compromises the validity of the informed consent
•A documented variceal hemorrhage within 4 months of screening
•Neutrophil count less than or equal to 1,500/mm3, platelet count less than or equal to 100,000/mm3, hemoglobin less than or equal to 8.5 g/dL, or a Prothrombin Time (INR) greater than 1.3 (vitamin K supplementation allowed)
•Serum creatinine greater than 1.1 times the upper limit of normal
•History of human immunodeficiency virus or acquired immune deficiency syndrome
•Use of an investigational drug or product or participation in a drug study within 30 days before dosing
•Liver function defined as: serum bilirubin greater than 1.5 times the upper limit of normal or an aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 5 times upper limit of normal, or serum albumin less than 3.2 g/dL
•History of gout or abnormal uric acid metabolism
•The clinical presence of ascites
•Treatment of HCC within 30 days of screening by chemotherapy or treatment of the target lesion(s) by chemoembolization, PEI, or surgery
•Radiofrequency ("RF") ablation of the target lesion(s) within 60 days of screening
•Subjects with a life expectancy of less than 12 weeks
•Subjects having received an organ transplant
•Subjects currently receiving coumadin or heparin
•Pregnant or nursing women